INVIVO DETECTION OF METABOLIC CHANGES IN A MOUSE MODEL OF SCRAPIE USING NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY

TY - JOUR

T1 - INVIVO DETECTION OF METABOLIC CHANGES IN A MOUSE MODEL OF SCRAPIE USING NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY

AU - BELL, J D

AU - COX, I J

AU - WILLIAMS, S C R

AU - BELTON, P S

AU - MCCONNELL, I

AU - HOPE, J

PY - 1991/10

Y1 - 1991/10

N2 - In vivo proton nuclear magnetic resonance (NMR) spectroscopy studies of scrapie in a mouse model have shown the appearance of an abnormal peak in the brain early in the incubation period. This abnormal peak was detected weeks before the detection of a protease-resistant form of a membrane protein and vacuolar histopathology in vitro, and several months before clinical signs, and the signal increased in intensity as the disease progressed. In the chronic stage of the disease, a reduction in N-acetyl aspartate levels was observed using in vivo and in vitro proton NMR spectroscopy.

AB - In vivo proton nuclear magnetic resonance (NMR) spectroscopy studies of scrapie in a mouse model have shown the appearance of an abnormal peak in the brain early in the incubation period. This abnormal peak was detected weeks before the detection of a protease-resistant form of a membrane protein and vacuolar histopathology in vitro, and several months before clinical signs, and the signal increased in intensity as the disease progressed. In the chronic stage of the disease, a reduction in N-acetyl aspartate levels was observed using in vivo and in vitro proton NMR spectroscopy.

U2 - 10.1099/0022-1317-72-10-2419

DO - 10.1099/0022-1317-72-10-2419

M3 - Article

SN - 0022-1317

VL - 72

SP - 2419

EP - 2423

JO - Journal of General Virology

JF - Journal of General Virology

ER -