Involvement of Autoimmunity in the Pathogenesis of Aggressive Periodontitis

A. Hendler; T. K. Mulli; F. J. Hughes; D. Perrett; M. Bombardieri; Y. Houri-Haddad; E. I. Weiss; A. Nissim

doi:10.1177/0022034510381903

Involvement of Autoimmunity in the Pathogenesis of Aggressive Periodontitis

A. Hendler, T. K. Mulli, F. J. Hughes, D. Perrett, M. Bombardieri, Y. Houri-Haddad, E. I. Weiss, A. Nissim

Centre for Oral, Clinical & Translational Sciences

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of periodontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n = 18) were tested for the presence of autoantibodies against: (a) native collagen type I (CI) and collagen type III (CIII); (b) CI and CIII post-translationally modified by reactive oxygen species (ROS) of the type present during inflammation; and (c) citrullinated filaggrin-derived peptides (CCP). Autoantibodies to native and ROS-modified CI and CIII as well as autoantibodies to CCP were observed exclusively in patients with AgP and not in those with CP or G. In conclusion, autoimmune reactions to native and post-translationally modified self-antigens may play a role specifically in the pathogenesis of AgP.

Original language	English
Pages (from-to)	1389 - 1394
Number of pages	6
Journal	Journal of Dental Research
Volume	89
Issue number	12
DOIs	https://doi.org/10.1177/0022034510381903
Publication status	Published - Dec 2010

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title = "Involvement of Autoimmunity in the Pathogenesis of Aggressive Periodontitis",

abstract = "The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of periodontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n = 18) were tested for the presence of autoantibodies against: (a) native collagen type I (CI) and collagen type III (CIII); (b) CI and CIII post-translationally modified by reactive oxygen species (ROS) of the type present during inflammation; and (c) citrullinated filaggrin-derived peptides (CCP). Autoantibodies to native and ROS-modified CI and CIII as well as autoantibodies to CCP were observed exclusively in patients with AgP and not in those with CP or G. In conclusion, autoimmune reactions to native and post-translationally modified self-antigens may play a role specifically in the pathogenesis of AgP.",

author = "A. Hendler and Mulli, {T. K.} and Hughes, {F. J.} and D. Perrett and M. Bombardieri and Y. Houri-Haddad and Weiss, {E. I.} and A. Nissim",

year = "2010",

month = dec,

doi = "10.1177/0022034510381903",

language = "English",

volume = "89",

pages = "1389 -- 1394",

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issn = "1544-0591",

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T1 - Involvement of Autoimmunity in the Pathogenesis of Aggressive Periodontitis

AU - Hendler, A.

AU - Mulli, T. K.

AU - Hughes, F. J.

AU - Perrett, D.

AU - Bombardieri, M.

AU - Houri-Haddad, Y.

AU - Weiss, E. I.

AU - Nissim, A.

PY - 2010/12

Y1 - 2010/12

N2 - The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of periodontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n = 18) were tested for the presence of autoantibodies against: (a) native collagen type I (CI) and collagen type III (CIII); (b) CI and CIII post-translationally modified by reactive oxygen species (ROS) of the type present during inflammation; and (c) citrullinated filaggrin-derived peptides (CCP). Autoantibodies to native and ROS-modified CI and CIII as well as autoantibodies to CCP were observed exclusively in patients with AgP and not in those with CP or G. In conclusion, autoimmune reactions to native and post-translationally modified self-antigens may play a role specifically in the pathogenesis of AgP.

AB - The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of periodontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n = 18) were tested for the presence of autoantibodies against: (a) native collagen type I (CI) and collagen type III (CIII); (b) CI and CIII post-translationally modified by reactive oxygen species (ROS) of the type present during inflammation; and (c) citrullinated filaggrin-derived peptides (CCP). Autoantibodies to native and ROS-modified CI and CIII as well as autoantibodies to CCP were observed exclusively in patients with AgP and not in those with CP or G. In conclusion, autoimmune reactions to native and post-translationally modified self-antigens may play a role specifically in the pathogenesis of AgP.

U2 - 10.1177/0022034510381903

DO - 10.1177/0022034510381903

M3 - Article

SN - 1544-0591

VL - 89

SP - 1389

EP - 1394

JO - Journal of Dental Research

JF - Journal of Dental Research

IS - 12

ER -

Involvement of Autoimmunity in the Pathogenesis of Aggressive Periodontitis

Abstract

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