Involvement of NADPH oxidases in cardiac remodelling and heart failure

TY - JOUR

T1 - Involvement of NADPH oxidases in cardiac remodelling and heart failure

AU - Sirker, A

AU - Zhang, M

AU - Murdoch, C

AU - Shah, A M

PY - 2007/10

Y1 - 2007/10

N2 - Cardiac remodelling occurs in response to stress, such as chronic hypertension or myocardial infarction, and forms the substrate for subsequent development of heart failure. Key pathophysiological features include ventricular hypertrophy, interstitial fibrosis, contractile dysfunction, and chamber dilatation. Although the molecular mechanisms are complex and not fully defined, substantial evidence now implicates increased oxidative stress as being important. The NADPH oxidase ('Nox') enzymes are a particularly important source of reactive oxygen species that are implicated in redox signalling. This article reviews the evidence for an involvement of NADPH oxidases in different aspects of adverse cardiac remodelling. A better understanding of the roles of this complex enzyme family may define novel therapeutic targets for the prevention of heart failure. Copyright (C) 2007 S. Karger AG, Basel

AB - Cardiac remodelling occurs in response to stress, such as chronic hypertension or myocardial infarction, and forms the substrate for subsequent development of heart failure. Key pathophysiological features include ventricular hypertrophy, interstitial fibrosis, contractile dysfunction, and chamber dilatation. Although the molecular mechanisms are complex and not fully defined, substantial evidence now implicates increased oxidative stress as being important. The NADPH oxidase ('Nox') enzymes are a particularly important source of reactive oxygen species that are implicated in redox signalling. This article reviews the evidence for an involvement of NADPH oxidases in different aspects of adverse cardiac remodelling. A better understanding of the roles of this complex enzyme family may define novel therapeutic targets for the prevention of heart failure. Copyright (C) 2007 S. Karger AG, Basel

U2 - 10.1159/000109148

DO - 10.1159/000109148

M3 - Literature review

VL - 27

SP - 649

EP - 660

JO - American Journal of Nephrology

JF - American Journal of Nephrology

IS - 6

ER -