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Iron(II)/Persulfate Mediated Newman-Kwart Rearrangement

Research output: Contribution to journalArticle

Thibault Gendron, Raul Geraldo Pereira, Hafsa Abdi, Timothy Howard Witney, Erik Arstad

Original languageEnglish
Pages (from-to)274-278
Number of pages5
JournalORGANIC LETTERS
Volume22
Issue number1
DOIs
Publication statusPublished - 3 Jan 2020

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Abstract

Herein, we report that iron(II)/ammonium persulfate in aqueous acetonitrile mediates the Newman-Kwart rearrangement of O-aryl carbamothioates. Electron-rich substrates react rapidly under moderate heating to afford the rearranged products in excellent yields. The mild conditions, rapid reaction rates, and suitability for scale up offers immediate practical benefits to access functionalized thiophenols.

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