TY - JOUR
T1 - Irregular sleep habits, regional grey matter volumes, and psychological functioning in adolescents
AU - The IMAGEN Consortium
AU - Lapidaire, Winok
AU - Urrila, Anna S.
AU - Artiges, Eric
AU - Miranda, Ruben
AU - Vulser, Helene
AU - Bezivin-Frere, Pauline
AU - Lemaitre, Herve
AU - Penttila, Jani
AU - Banaschewski, Tobias
AU - Bokde, Arun L.W.
AU - Bromberg, Uli
AU - Buchel, Christian
AU - Conrod, Patricia J.
AU - Desrivières, Sylvane
AU - Frouin, Vincent
AU - Gallinat, Jurgen
AU - Garavan, Hugh
AU - Gowland, Penny
AU - Heinz, Andreas
AU - Ittermann, B.
AU - Papadopoulos-Orfanos, Dimitri
AU - Paus, Tomas
AU - Smolka, Michael N.
AU - Schumann, Gunter
AU - Martinot, Marie Laure Paillere
AU - Martinot, Jean Luc
AU - Fauth-Buhler, M.
AU - Poutska, L.
AU - Nees, F.
AU - Grimmer, Y.
AU - Struve, M.
AU - Strohle, A.
AU - Kappel, V.
AU - Van Noort, B. M.
AU - Bordas, N.
AU - Bricaud, Z.
AU - Filippi, I.
AU - Galinowski, A.
AU - Gollier-Briant, F.
AU - Menard, Vincent
AU - Cattrell, A.
AU - Goodman, R.
AU - Stringaris, A.
AU - Nymberg, C.
AU - Reed, L.
AU - Ittermann, B.
AU - Bruhl R, R.
AU - Hubner, T.
AU - Muller, K.
AU - Bromberg, U.
N1 - Funding Information:
This study was funded by the European Union-funded FP6 Integrated Project IMAGEN (LSHM-CT-2007-037286), agence nationale de la recherche (ANR-12-SAMA-0004 and ANR-19- CE37-0017-03), Eranet (ANR-18-NEUR00002-01- ADORe and AF12-NEUR0008-01 - WM2NA), Fondation pour la Recherche M?dicale (DPA20140629802), Mission Interminist?rielle de Lutte Contre les Drogues et les Conduites Addictives, and Fondation de France (00081242) in the form of grants awarded to JLM. This study was also funded by the F?d?ration pour la Recherche sur le Cerveau in the form of a grant awarded to MLP and JLM. This study was also funded by the Academy of Finland (276612), Emil Aaltosen S??ti? Foundation, and Jalmari ja Rauha Ahokkaan S??ti? Foundation in the form of grants awarded to ASU and in the form of grants from IDEX Paris Saclay and INSERM - APHP 2010 interface grant awarded to HV.
Publisher Copyright:
© 2021 Lapidaire et al.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/2
Y1 - 2021/2
N2 - Changing sleep rhythms in adolescents often lead to sleep deficits and a delay in sleep timing between weekdays and weekends. The adolescent brain, and in particular the rapidly developing structures involved in emotional control, are vulnerable to external and internal factors. In our previous study in adolescents at age 14, we observed a strong relationship between weekend sleep schedules and regional medial prefrontal cortex grey matter volumes. Here, we aimed to assess whether this relationship remained in this group of adolescents of the general population at the age of 16 (n = 101; mean age 16.8 years; 55% girls). We further examined grey matter volumes in the hippocampi and the amygdalae, calculated with voxel-based morphometry. In addition, we investigated the relationships between sleep habits, assessed with self-reports, and regional grey matter volumes, and psychological functioning, assessed with the Strengths and Difficulties Questionnaire and tests on working memory and impulsivity. Later weekend wake-up times were associated with smaller grey matter volumes in the medial prefrontal cortex and the amygdalae, and greater weekend delays in wake-up time were associated with smaller grey matter volumes in the right hippocampus and amygdala. The medial prefrontal cortex region mediated the correlation between weekend wake up time and externalising symptoms. Paying attention to regular sleep habits during adolescence could act as a protective factor against the emergence of psychopathology via enabling favourable brain development.
AB - Changing sleep rhythms in adolescents often lead to sleep deficits and a delay in sleep timing between weekdays and weekends. The adolescent brain, and in particular the rapidly developing structures involved in emotional control, are vulnerable to external and internal factors. In our previous study in adolescents at age 14, we observed a strong relationship between weekend sleep schedules and regional medial prefrontal cortex grey matter volumes. Here, we aimed to assess whether this relationship remained in this group of adolescents of the general population at the age of 16 (n = 101; mean age 16.8 years; 55% girls). We further examined grey matter volumes in the hippocampi and the amygdalae, calculated with voxel-based morphometry. In addition, we investigated the relationships between sleep habits, assessed with self-reports, and regional grey matter volumes, and psychological functioning, assessed with the Strengths and Difficulties Questionnaire and tests on working memory and impulsivity. Later weekend wake-up times were associated with smaller grey matter volumes in the medial prefrontal cortex and the amygdalae, and greater weekend delays in wake-up time were associated with smaller grey matter volumes in the right hippocampus and amygdala. The medial prefrontal cortex region mediated the correlation between weekend wake up time and externalising symptoms. Paying attention to regular sleep habits during adolescence could act as a protective factor against the emergence of psychopathology via enabling favourable brain development.
UR - http://www.scopus.com/inward/record.url?scp=85101418009&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0243720
DO - 10.1371/journal.pone.0243720
M3 - Article
AN - SCOPUS:85101418009
SN - 1932-6203
VL - 16
JO - PLoS ONE
JF - PLoS ONE
IS - 2
M1 - e0243720
ER -