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Is imprinting the result of “friendly fire” by the host defense system?

Research output: Contribution to journalReview article

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Is imprinting the result of “friendly fire” by the host defense system? / Ondičová, Miroslava; Oakey, Rebecca J.; Walsh, Colum P.

In: PLoS Genetics, Vol. 16, No. 4, e1008599, 04.2020.

Research output: Contribution to journalReview article

Harvard

Ondičová, M, Oakey, RJ & Walsh, CP 2020, 'Is imprinting the result of “friendly fire” by the host defense system?', PLoS Genetics, vol. 16, no. 4, e1008599. https://doi.org/10.1371/journal.pgen.1008599

APA

Ondičová, M., Oakey, R. J., & Walsh, C. P. (2020). Is imprinting the result of “friendly fire” by the host defense system? PLoS Genetics, 16(4), [e1008599]. https://doi.org/10.1371/journal.pgen.1008599

Vancouver

Ondičová M, Oakey RJ, Walsh CP. Is imprinting the result of “friendly fire” by the host defense system? PLoS Genetics. 2020 Apr;16(4). e1008599. https://doi.org/10.1371/journal.pgen.1008599

Author

Ondičová, Miroslava ; Oakey, Rebecca J. ; Walsh, Colum P. / Is imprinting the result of “friendly fire” by the host defense system?. In: PLoS Genetics. 2020 ; Vol. 16, No. 4.

Bibtex Download

@article{970c2b1cc2634aee9015814e255444ec,
title = "Is imprinting the result of “friendly fire” by the host defense system?",
abstract = "In 1993, Denise Barlow proposed that genomic imprinting might have arisen from a host defense mechanism designed to inactivate retrotransposons. Although there were few examples at hand, she suggested that there should be maternal-specific and paternal-specific factors involved, with cognate imprinting boxes that they recognized; furthermore, the system should build on conserved biochemical factors, including DNA methylation, and maternal control should predominate for imprints. Here, we revisit this hypothesis in the light of recent advances in our understanding of host defense and DNA methylation and in particular, the link with Kr{\"u}ppel-associated box–zinc finger (KRAB-ZF) proteins.",
author = "Miroslava Ondičov{\'a} and Oakey, {Rebecca J.} and Walsh, {Colum P.}",
year = "2020",
month = "4",
doi = "10.1371/journal.pgen.1008599",
language = "English",
volume = "16",
journal = "PL o S Genetics",
issn = "1553-7390",
number = "4",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Is imprinting the result of “friendly fire” by the host defense system?

AU - Ondičová, Miroslava

AU - Oakey, Rebecca J.

AU - Walsh, Colum P.

PY - 2020/4

Y1 - 2020/4

N2 - In 1993, Denise Barlow proposed that genomic imprinting might have arisen from a host defense mechanism designed to inactivate retrotransposons. Although there were few examples at hand, she suggested that there should be maternal-specific and paternal-specific factors involved, with cognate imprinting boxes that they recognized; furthermore, the system should build on conserved biochemical factors, including DNA methylation, and maternal control should predominate for imprints. Here, we revisit this hypothesis in the light of recent advances in our understanding of host defense and DNA methylation and in particular, the link with Krüppel-associated box–zinc finger (KRAB-ZF) proteins.

AB - In 1993, Denise Barlow proposed that genomic imprinting might have arisen from a host defense mechanism designed to inactivate retrotransposons. Although there were few examples at hand, she suggested that there should be maternal-specific and paternal-specific factors involved, with cognate imprinting boxes that they recognized; furthermore, the system should build on conserved biochemical factors, including DNA methylation, and maternal control should predominate for imprints. Here, we revisit this hypothesis in the light of recent advances in our understanding of host defense and DNA methylation and in particular, the link with Krüppel-associated box–zinc finger (KRAB-ZF) proteins.

UR - http://www.scopus.com/inward/record.url?scp=85083191598&partnerID=8YFLogxK

U2 - 10.1371/journal.pgen.1008599

DO - 10.1371/journal.pgen.1008599

M3 - Review article

C2 - 32271759

AN - SCOPUS:85083191598

VL - 16

JO - PL o S Genetics

JF - PL o S Genetics

SN - 1553-7390

IS - 4

M1 - e1008599

ER -

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