Is methicillin-resistant Staphylococcus aureus more virulent than methicillin-susceptible S-aureus? A comparative cohort study of British patients with nosocomial infection and bacteremia

M Melzer, S J Eykyn, W R Gransden, S Chinn

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212 Citations (Scopus)

Abstract

Staphylococcus aureus is the most common cause of hospital-acquired bacteremia. From 1995 through 2000, data on age, sex, patient specialty at time of first bacteremia, primary and secondary sites of infection, delay in initiating antimicrobial therapy, and patient outcome were prospectively recorded for 815 patients with nosocomial S. aureus bacteremia. The proportion of patients whose death was attributable to methicillin-resistant S. aureus (MRSA) was significantly higher than that for methicillin-susceptible S. aureus (MSSA) (11.8% vs. 5.1%; odds ratio [OR], 2.49; 95% confidence interval [CI], 1.46-4.24; P
Original languageEnglish
Pages (from-to)1453 - 1460
Number of pages8
JournalClinical Infectious Diseases
Volume37
Issue number11
DOIs
Publication statusPublished - 1 Dec 2003

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