Is the relationship between erythropoiesis and renal function one of the secrets of extreme longevity?

Giorgio Basile, Federica Bellone, Antonino Catalano, Giuseppe Maltese, Francesco Corica, Giovanni Squadrito, Roberto Scicali, Giuseppe Mandraffino

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Background and aims
Renal function and erythropoiesis could be impaired with advancing age. Neutrophil gelatinase-associated lipocalin (NGAL) as well as erythropoietin (EPO) levels are two useful biomarkers of the renal status. In advanced age, the relationships between NGAL, EPO and hemoglobin (Hb) levels remains unknown. The aim of the present study is to evaluate the relationship between renal function and erythropoiesis in a small cohort of centenarians.

Methods and results
We observed thirty-one healthy centenarians with normal hemoglobin levels, a mild reduction in eGFR and no need of erythropoiesis support. We found a significant inverse association between NGAL and GFR, hemoglobin levels and EPO, confirming the key role of the renal function on erythropoiesis also in extreme longevity. A gender difference emerged, showing female participants with lower eGFR and Hb values more than males.

Our findings suggested a new link between renal function, erythropoiesis and longevity in centenarians and these could have relevant implications in clinical practice. These findings could explain why very old subjects presenting a slight GFR reduction seemed not to be exposed to a significant risk of mortality.
Original languageEnglish
Pages (from-to)868-872
Number of pages5
JournalNutrition, Metabolism and Cardiovascular Diseases
Issue number4
Early online date30 Jan 2023
Publication statusPublished - Apr 2023


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