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Is there a common underlying mechanism for age-related decline in cortical thickness?

Research output: Contribution to journalArticle

Christine Ecker, Daniel Stahl, Eileen Daly, Patrick Johnston, Alexander Thomson, Declan G. M. Murphy

Original languageEnglish
Pages (from-to)1155 - 1160
Number of pages6
Issue number13
Publication statusPublished - Aug 2009

King's Authors


The aim of this study was to derive a causal model of age-related grey matter atrophy across the cortex on the basis of cortical thickness measures using surface reconstruction of structural magnetic resonance images. Using confirmatory factor analysis, it was shown that the observed interregional correlations matrix between thickness measures could most accurately be accounted for by a single common age-related mechanism. This common factor did not predict cortical thickness directly, but exerted differential effects on individual region through independent lobe-specific systems. This model reconciles two seemingly mutually exclusive hypotheses, namely, the existence of different decay functions being caused by the same underlying mechanism. NeuroReport 20:1155-1160 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

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