Abstract
Introduction
For cancer patients, immune checkpoint inhibitors (ICIs) produce superior long-term responses compared to alternative treatments, albeit at the cost of manifesting adverse immune-related events. There are many hypotheses of the impacts of physical activities in immunotherapy, but little is known about the oncological outcomes and the underlying mechanisms. This scoping review aims to identify possible physical activity interventions, their efficacy and feasibility, and the potential underlying biological mechanisms responsible for their effects.
Method and analysis
The Levac methodology framework was used along with guidance from the Joanna Briggs Institute (JBI) Manual for Evidence Synthesis to inform development of this protocol. Abstracts and titles followed by full-text screening will be performed by two independent reviewers for inclusion. All studies describing the impact of physical activities and exercise interventions on cancer ICIs, with particular focus upon oncological outcomes, quality of life or underling biological mechanisms, will be included. After extracting qualitative and quantitative data, they will be evaluated and summarised respectively. Subsequently, a further consultation step with other scientists and healthcare professionals will be performed.
Ethics and dissemination
The research findings will be published through an open-access peer-reviewed journal. The results of this scoping review will be used to inform further studies on physical impacts on immunotherapy. All data included will be from open resources therefore no ethical clearances are required.
For cancer patients, immune checkpoint inhibitors (ICIs) produce superior long-term responses compared to alternative treatments, albeit at the cost of manifesting adverse immune-related events. There are many hypotheses of the impacts of physical activities in immunotherapy, but little is known about the oncological outcomes and the underlying mechanisms. This scoping review aims to identify possible physical activity interventions, their efficacy and feasibility, and the potential underlying biological mechanisms responsible for their effects.
Method and analysis
The Levac methodology framework was used along with guidance from the Joanna Briggs Institute (JBI) Manual for Evidence Synthesis to inform development of this protocol. Abstracts and titles followed by full-text screening will be performed by two independent reviewers for inclusion. All studies describing the impact of physical activities and exercise interventions on cancer ICIs, with particular focus upon oncological outcomes, quality of life or underling biological mechanisms, will be included. After extracting qualitative and quantitative data, they will be evaluated and summarised respectively. Subsequently, a further consultation step with other scientists and healthcare professionals will be performed.
Ethics and dissemination
The research findings will be published through an open-access peer-reviewed journal. The results of this scoping review will be used to inform further studies on physical impacts on immunotherapy. All data included will be from open resources therefore no ethical clearances are required.
| Original language | English |
|---|---|
| Type | Protocol |
| Publisher | BMJ and BMJ Publishing |
| Place of Publication | BMJ Open |
| DOIs | |
| Publication status | Published - 8 Oct 2021 |
