Is there a role for physical activity when treating patients with cancer with immune checkpoint inhibitors?: Protocol for a scoping review

Miaoqi Chen; Ridesh Raj; Louis Fox; Charlotte Louise Moss; Gincy George; Sophia N Karagiannis; Deborah Enting; Magdalene Joseph; Nicola Peat; Beth Russell; Mieke Van Hemelrijck

doi:10.1136/bmjopen-2020-046052

Is there a role for physical activity when treating patients with cancer with immune checkpoint inhibitors? Protocol for a scoping review

Miaoqi Chen, Ridesh Raj, Louis Fox, Charlotte Louise Moss, Gincy George, Sophia N Karagiannis, Deborah Enting, Magdalene Joseph, Nicola Peat, Beth Russell, Mieke Van Hemelrijck

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Abstract

INTRODUCTION: For patients with cancer, immune checkpoint inhibitors (ICIs) produce superior long-term responses compared with alternative treatments, although at the cost of manifesting adverse immune-related events. There are many hypotheses of the impacts of physical activities in immunotherapy, but little is known about the oncological outcomes and the underlying mechanisms. This scoping review aims to identify possible physical activity interventions, their efficacy and feasibility and the potential underlying biological mechanisms responsible for their effects.

METHOD AND ANALYSIS: The Levac methodology framework was used along with guidance from the Joanna Briggs Institute Manual for Evidence Synthesis to inform development of this protocol. Abstracts and titles followed by full-text screening will be performed by two independent reviewers for inclusion. All studies describing the impact of physical activities and exercise interventions on cancer ICIs, with particular focus on oncological outcomes, quality of life or underling biological mechanisms, will be included. After extracting qualitative and quantitative data, they will be evaluated and summarised, respectively. Subsequently, a further consultation step with other scientists and healthcare professionals will be performed.

ETHICS AND DISSEMINATION: The research findings will be published through an open-access peer-reviewed journal. The results of this scoping review will be used to inform further studies on physical impacts on immunotherapy. All data included will be from open resources, therefore, no ethical clearances are required.

Original language	English
Article number	e046052
Pages (from-to)	e046052
Journal	BMJ Open
Volume	11
Issue number	10
DOIs	https://doi.org/10.1136/bmjopen-2020-046052
Publication status	Published - 8 Oct 2021

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Chen et al BMJ Open e046052.fullFinal published version, 321 KBLicence: CC BY

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Chen, M., Raj, R., Fox, L., Moss, C. L., George, G., Karagiannis, S. N., Enting, D., Joseph, M., Peat, N., Russell, B., & Van Hemelrijck, M. (2021). Is there a role for physical activity when treating patients with cancer with immune checkpoint inhibitors? Protocol for a scoping review. BMJ Open, 11(10), e046052. Article e046052. https://doi.org/10.1136/bmjopen-2020-046052

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abstract = "INTRODUCTION: For patients with cancer, immune checkpoint inhibitors (ICIs) produce superior long-term responses compared with alternative treatments, although at the cost of manifesting adverse immune-related events. There are many hypotheses of the impacts of physical activities in immunotherapy, but little is known about the oncological outcomes and the underlying mechanisms. This scoping review aims to identify possible physical activity interventions, their efficacy and feasibility and the potential underlying biological mechanisms responsible for their effects.METHOD AND ANALYSIS: The Levac methodology framework was used along with guidance from the Joanna Briggs Institute Manual for Evidence Synthesis to inform development of this protocol. Abstracts and titles followed by full-text screening will be performed by two independent reviewers for inclusion. All studies describing the impact of physical activities and exercise interventions on cancer ICIs, with particular focus on oncological outcomes, quality of life or underling biological mechanisms, will be included. After extracting qualitative and quantitative data, they will be evaluated and summarised, respectively. Subsequently, a further consultation step with other scientists and healthcare professionals will be performed.ETHICS AND DISSEMINATION: The research findings will be published through an open-access peer-reviewed journal. The results of this scoping review will be used to inform further studies on physical impacts on immunotherapy. All data included will be from open resources, therefore, no ethical clearances are required.",

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Is there a role for physical activity when treating patients with cancer with immune checkpoint inhibitors? Protocol for a scoping review

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