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Is there an increased risk of perinatal mental disorder in women with gestational diabetes? A systematic review and meta‐analysis

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Number of pages21
JournalDiabetic Medicine
Issue number4
Early online date6 Nov 2019
Accepted/In press4 Nov 2019
E-pub ahead of print6 Nov 2019

Bibliographical note

Funding Information: CW carried out this work as part of a Medical Research Council (MRC) funded Clinical Research Training Fellowship (MR/P019293/1). Publisher Copyright: © 2019 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK


King's Authors



Gestational diabetes (GDM) and mental disorder are common perinatal morbidities and are associated with adverse maternal and child outcomes. While there is a relationship between type 2 diabetes and mental disorder, the relationship between GDM and mental disorder has been less studied. We conducted a systematic review and meta‐analysis of the prevalence of mental disorders in women with GDM and their risk for mental disorders compared with women without GDM.


Published, peer‐reviewed literature measuring prevalence and/or odds of GDM and perinatal mental disorders was reviewed systematically. Risk of bias was assessed using a checklist. Two independent reviewers were involved. Analyses were grouped by stage of peripartum, i.e. antepartum at the time of GDM diagnosis and after diagnosis, and in the postpartum.


Sixty‐two studies were included. There was an increased risk of depressive symptoms in the antenatal period around the time of diagnosis of GDM [odds ratio (OR) 2.08; 95% confidence interval (CI) 1.42, 3.05] and in the postnatal period (OR 1.59; 95% CI 1.26, 2.00).


Given the potential relationship between GDM and perinatal mental disorders, integration of physical and mental healthcare in women experiencing GDM and mental disorders could improve short‐ and long‐term outcomes for women and their children.

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