Is there rebound psychosis on withdrawal of antipsychotic medication in schizophrenia?

Matthew John Taylor, Sebastian Yim

Research output: Contribution to journalLetterpeer-review

5 Citations (Scopus)
184 Downloads (Pure)

Abstract

Antipsychotic medications are widely used to prevent relapse in schizophrenia, but some suggest that their apparent benefit could be inflated by early rebound psychosis on medication withdrawal. This was investigated by analysis of time to event data from randomized trials. Over the six months following randomisation, continuation is associated with fewer relapses HR 0.38 (95%CI 0.32 to 0.44), similarly within the first month HR 0.46 (95%CI 0.36 to 0.59). These data confirm a lower risk of relapse in those continuing antipsychotic medications in the short term. No general early rebound phenomenon is seen on medication discontinuation.
Original languageEnglish
JournalSchizophrenia Research
Early online date8 Jun 2018
DOIs
Publication statusE-pub ahead of print - 8 Jun 2018

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