TY - JOUR
T1 - Isolation and expression of the homeobox gene Gbx1 during mouse development
AU - Rhinn, M
AU - Lun, K
AU - Werner, M
AU - Simeone, A
AU - Brand, M
PY - 2004/2
Y1 - 2004/2
N2 - In zebrafish, gbx1 and otx2 are among the earliest genes expressed in the neuroectoderm, dividing it into an anterior and a posterior domain with a common border that marks the midbrain-hindbrain boundary (MHB) primordium. Here, we describe the sequence and expression pattern of Gbx1 in mouse. The first transcripts are found at embryonic day 7.75 in the hindbrain. Later on, expression of Gbx1 is detectable in the hindbrain (rhombomeres 2 to 7), spinal cord, optic vesicles, and in the ventral telencephalon. In mouse, Gbx1 expression is not observed at the MHB as is the case during early zebrafish development. We suggest that an evolutionary switch occurred: in mouse Gbx2 is involved in the early specification of the MHB primordium, whereas in zebrafish, gbx1 is required instead of gbx2.
AB - In zebrafish, gbx1 and otx2 are among the earliest genes expressed in the neuroectoderm, dividing it into an anterior and a posterior domain with a common border that marks the midbrain-hindbrain boundary (MHB) primordium. Here, we describe the sequence and expression pattern of Gbx1 in mouse. The first transcripts are found at embryonic day 7.75 in the hindbrain. Later on, expression of Gbx1 is detectable in the hindbrain (rhombomeres 2 to 7), spinal cord, optic vesicles, and in the ventral telencephalon. In mouse, Gbx1 expression is not observed at the MHB as is the case during early zebrafish development. We suggest that an evolutionary switch occurred: in mouse Gbx2 is involved in the early specification of the MHB primordium, whereas in zebrafish, gbx1 is required instead of gbx2.
UR - http://www.scopus.com/inward/record.url?scp=0942287277&partnerID=8YFLogxK
U2 - 10.1002/dvdy.10435
DO - 10.1002/dvdy.10435
M3 - Article
SN - 1097-0177
VL - 229
SP - 334
EP - 339
JO - Developmental Dynamics
JF - Developmental Dynamics
IS - 2
ER -