TY - JOUR
T1 - It is Rocket Science - Why dietary nitrate is hard to beet! Part I
T2 - Twists and turns in the realisation of the nitrate-nitrite-NO pathway
AU - Khatri, Jibran
AU - Mills, Charlotte Elizabeth
AU - Maskell, Perry
AU - Odongerel, Chimed
AU - Webb, Andrew James
N1 - This article is protected by copyright. All rights reserved.
PY - 2016/2/20
Y1 - 2016/2/20
N2 - Dietary nitrate (found in green leafy vegetables such as rocket and in beetroot) is now recognised to be an important source of nitric oxide, via the nitrate-nitrite-NO pathway. Dietary nitrate confers several cardiovascular beneficial effects on blood pressure, platelets, endothelial function, mitochondrial efficiency and exercise. Whilst this pathway may now seem obvious, its realisation followed a rather tortuous course over two decades. Early steps included the discovery that nitrite was a source of NO in the ischaemic heart, but this appeared to have deleterious effects. In addition, nitrate-derived nitrite provided a gastric source of NO. However, residual nitrite was not thought to be absorbed systemically. Nitrite was also considered to be physiologically inert, but potentially carcinogenic, through N-nitrosamine formation. In Part I we describe key twists and turns in the elucidation of the pathway and the underlying mechanisms. This provides the critical foundation for the more recent developments in the nitrate-nitrite-NO pathway which are covered in Part II. This article is protected by copyright. All rights reserved.
AB - Dietary nitrate (found in green leafy vegetables such as rocket and in beetroot) is now recognised to be an important source of nitric oxide, via the nitrate-nitrite-NO pathway. Dietary nitrate confers several cardiovascular beneficial effects on blood pressure, platelets, endothelial function, mitochondrial efficiency and exercise. Whilst this pathway may now seem obvious, its realisation followed a rather tortuous course over two decades. Early steps included the discovery that nitrite was a source of NO in the ischaemic heart, but this appeared to have deleterious effects. In addition, nitrate-derived nitrite provided a gastric source of NO. However, residual nitrite was not thought to be absorbed systemically. Nitrite was also considered to be physiologically inert, but potentially carcinogenic, through N-nitrosamine formation. In Part I we describe key twists and turns in the elucidation of the pathway and the underlying mechanisms. This provides the critical foundation for the more recent developments in the nitrate-nitrite-NO pathway which are covered in Part II. This article is protected by copyright. All rights reserved.
U2 - 10.1111/bcp.12913
DO - 10.1111/bcp.12913
M3 - Article
C2 - 26896747
SN - 0306-5251
JO - British Journal of Clinical Pharmacology
JF - British Journal of Clinical Pharmacology
ER -