Kidney Beam - a cost-effective digital intervention to improve mental health

TY - JOUR

T1 - Kidney Beam - a cost-effective digital intervention to improve mental health

AU - Greenwood, Sharlene A.

AU - Briggs, Juliet

AU - Walklin, Christy

AU - Mangahis, Emmanuel

AU - Young, Hannah M.L

AU - Castle, Ellen M.

AU - Billany, Roseanne E

AU - Asgari, Elham

AU - Bhandari, Sunil

AU - Bishop, Nicolette

AU - Bramham, Kate

AU - Burton, James O

AU - Campbell, Jackie

AU - Chilcot, Joseph

AU - Cooper, Nicola

AU - Deelchand, Vashist

AU - Graham-Brown, M.P.M

AU - Haggis, Lynda

AU - Hamilton, Alexander

AU - Jesky, Mark

AU - Kalra, Philip A

AU - Koufaki, Pelagia

AU - McCafferty, Kieran

AU - Nixon, Andrew C

AU - Noble, Helen

AU - Saynor, Zoe L

AU - Taal, Maarten W

AU - Tollitt, James

AU - Wheeler, David C.

AU - Wilkinson, Thomas J

AU - Worboys, Hannah

AU - Macdonald, Jamie

N1 - Publisher Copyright: © 2024

PY - 2024/11/4

Y1 - 2024/11/4

N2 - Introduction: There is inequity in the provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention (DHI) in CKD. Methods: In a single-blind, 11 center, randomized controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity DHI or a waitlist control. This study assessed the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6-months, and cost-effectiveness of the intervention. Results: At 6-months, there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 [95% confidence interval, CI: 4.4–7.5] arbitrary units [AU], P < 0.0001), and a 93% and 98% chance of the intervention being cost-effective at a willingness-to-pay threshold of £20,000 and £30,000 per quality-adjusted life year gained. Conclusion: The Kidney BEAM physical activity DHI is a clinically valuable and cost-effective means to improve mental health-related quality of life (HRQoL) in people with CKD (trial registration no. NCT04872933).

AB - Introduction: There is inequity in the provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention (DHI) in CKD. Methods: In a single-blind, 11 center, randomized controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity DHI or a waitlist control. This study assessed the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6-months, and cost-effectiveness of the intervention. Results: At 6-months, there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 [95% confidence interval, CI: 4.4–7.5] arbitrary units [AU], P < 0.0001), and a 93% and 98% chance of the intervention being cost-effective at a willingness-to-pay threshold of £20,000 and £30,000 per quality-adjusted life year gained. Conclusion: The Kidney BEAM physical activity DHI is a clinically valuable and cost-effective means to improve mental health-related quality of life (HRQoL) in people with CKD (trial registration no. NCT04872933).

UR - https://www.scopus.com/pages/publications/85204784363

U2 - 10.1016/j.ekir.2024.08.030

DO - 10.1016/j.ekir.2024.08.030

M3 - Article

SN - 2468-0249

VL - 9

SP - 3204

EP - 3217

JO - Kidney International Reports

JF - Kidney International Reports

IS - 11

ER -