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Kidney disease in the setting of HIV infection: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Research output: Contribution to journalArticle

Charles R. Swanepoel, Mohamed G. Atta, Vivette D. D’Agati, Michelle M. Estrella, Agnes B. Fogo, Saraladevi Naicker, Frank A. Post, Nicola Wearne, Cheryl A. Winkler, Michael Cheung, David C. Wheeler, Wolfgang C. Winkelmayer, Christina M. Wyatt, Ali Abu-Alfa, Dwomoa Adu, Lawrence Y. Agodoa, Charles E. Alpers, Fatiu A. Arogundade, Gloria Ashuntantang, Corinne I. Bagnis & 29 more Raj Bhimma, Isabelle Brocheriou, Arthur H. Cohen, Karen Cohen, H. Terence Cook, Sophie de Seigneux, June Fabian, Fredric O. Finkelstein, Mark Haas, Lisa Hamzah, Bruce M. Hendry, Valentine Imonje, J. Charles Jennette, Paul L. Kimmel, Mary E. Klotman, Paul E. Klotman, Chris P. Larsen, Mignon I. McCulloch, Pulane Mosiane, Cynthia C. Nast, Ikechi G. Okpechi, Patricio E. Ray, Avi Z. Rosenberg, Michael J. Ross, Lene Ryom, Luan Truong, Ifeoma Ulasi, Liffert Vogt, Martin Zeier

Original languageEnglish
JournalKidney International
Early online date3 Feb 2018
DOIs
Publication statusE-pub ahead of print - 3 Feb 2018

King's Authors

Abstract

HIV-positive individuals are at increased risk for kidney disease, including HIV-associated nephropathy, noncollapsing focal segmental glomerulosclerosis, immune-complex kidney disease, and comorbid kidney disease, as well as kidney injury resulting from prolonged exposure to antiretroviral therapy or from opportunistic infections. Clinical guidelines for kidney disease prevention and treatment in HIV-positive individuals are largely extrapolated from studies in the general population, and do not fully incorporate existing knowledge of the unique HIV-related pathways and genetic factors that contribute to the risk of kidney disease in this population. We convened an international panel of experts in nephrology, renal pathology, and infectious diseases to define the pathology of kidney disease in the setting of HIV infection; describe the role of genetics in the natural history, diagnosis, and treatment of kidney disease in HIV-positive individuals; characterize the renal risk-benefit of antiretroviral therapy for HIV treatment and prevention; and define best practices for the prevention and management of kidney disease in HIV-positive individuals.

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