Kinetic modeling of 11C-SB207145 binding to 5-HT4 receptors in the human brain in vivo

Lisbeth Marner, Nic Gillings, Robert A Comley, William F C Baaré, Eugenii A Rabiner, Alan A Wilson, Sylvain Houle, Steen G Hasselbalch, Claus Svarer, Roger N Gunn, Marc Laruelle, Gitte M Knudsen

Research output: Contribution to journalArticlepeer-review

79 Citations (Scopus)

Abstract

The serotonin 4 receptor (5-HT(4) receptor) is known to be involved in learning and memory. We evaluated for the first time the quantification of a novel 5-HT(4) receptor radioligand, (11)C-SB207145, for in vivo brain imaging with PET in humans.
Original languageEnglish
Pages (from-to)900-8
Number of pages9
JournalJournal of Nuclear Medicine
Volume50
Issue number6
DOIs
Publication statusPublished - 2009

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