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Kisspeptin in the medial amygdala and sexual behavior in male rats

Research output: Contribution to journalArticle

Rebecca Gresham, Shengyun Li, Daniel A Adekunbi, Minghan Hu, Xiao Feng Li, Kevin T O'Byrne

Original languageEnglish
Pages (from-to)13-17
Number of pages5
JournalNeuroscience Letters
Early online date24 May 2016
Publication statusPublished - 3 Aug 2016


King's Authors


The medial amygdala (MeA) is crucial for sexual behavior; kisspeptin (Kiss1) also plays a role in sexual function. Kisspeptin receptor (Kiss1r) knockout mice display no sexual behavior. Recently Kiss1 and Kiss1r have been discovered in the posterodorsal subnucleus of the medial amygdala (MePD). We hypothesised that Kiss1 in the MePD may have an influence on male sexual behavior. To test this we bilaterally cannulated the MePD and infused kisspeptin-10 in male rats. This caused the rats to have multiple erections, an effect specific to Kiss1 receptor activation, because Kiss1r antagonism blocked the erectile response. When Kiss1 was infused into the lateral cerebroventricle, there were no observed erections. We also measured the plasma levels of LH when Kiss1 is infused into the MePD or lateral cerebroventricle; Kiss1 increased plasma LH to comparable levels when infused into both sites. We conclude that Kiss1 has a role in male sexual behavior, which is specific to the MePD.

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