Kv7 and Kv11 channels in myometrial regulation

Iain Greenwood; Rachel M Tribe

doi:10.1113/expphysiol.2013.075754

Kv7 and Kv11 channels in myometrial regulation

Iain Greenwood, Rachel M Tribe

Women & Children's Health

St George's, University of London

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Ion channels play a key role in defining myometrial contractility. Modulation of ion channels populations are proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescent to active labour. Of the myriad ion channels present in the uterus, this article will focus upon potassium channels encoded by the KCNQ genes and ether-a-go-go related genes (ERG). Voltage-gated potassium channels encoded by KCNQ and ERG (termed Kv7 and Kv11 respectively) are accepted as major determinants of neuronal excitability and the duration of the cardiac action potential. However, there is now growing appreciation that these ion channels have a major functional impact in vascular and non-vascular smooth muscle. Moreover, Kv7 channels may be potential therapeutic target for the treatment of preterm labour.

Original language	English
Pages (from-to)	503-509
Number of pages	7
Journal	Experimental Physiology,
Volume	99
Issue number	3
DOIs	https://doi.org/10.1113/expphysiol.2013.075754
Publication status	Published - 1 Mar 2014

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title = "Kv7 and Kv11 channels in myometrial regulation",

abstract = "Ion channels play a key role in defining myometrial contractility. Modulation of ion channels populations are proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescent to active labour. Of the myriad ion channels present in the uterus, this article will focus upon potassium channels encoded by the KCNQ genes and ether-a-go-go related genes (ERG). Voltage-gated potassium channels encoded by KCNQ and ERG (termed Kv7 and Kv11 respectively) are accepted as major determinants of neuronal excitability and the duration of the cardiac action potential. However, there is now growing appreciation that these ion channels have a major functional impact in vascular and non-vascular smooth muscle. Moreover, Kv7 channels may be potential therapeutic target for the treatment of preterm labour.",

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Kv7 and Kv11 channels in myometrial regulation

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