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La cascade excitotoxique et la neuroprotection aux différentes phases du développement cérébral

Research output: Contribution to journalArticle

P Evrard, S Marret, P Gressens

Original languageFrench
Pages (from-to)159-65; discussion 165-7
JournalBulletin et Memoires De L Academie Royale De Medecine De Belgique
Volume152
Issue number3
Publication statusPublished - 1997

King's Authors

Abstract

Prevalence of cerebral palsy enhanced dramatically during the last decades in some western countries. Pathophysiology of perinatal brain lesions has been revisited. Etiology seems multifactorial including perfusion failure/hypoxia, preconceptional factors, thyroid hormone and growth factors deficiencies, maternal infections with production of cytokines. Excitatory amino acids and excitotoxic cascade seem to be a common final pathway leading to neural cell death. Pharmacological tools destined to inhibit the excitotoxic cascade have been recently developed and are promising for neonatal "neuroprotection".

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