Labeling of cell therapies: How can we get it right?

Sonia Waiczies, Thoralf Niendorf, Giovanna Lombardi

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    Labeling cells for non-invasive tracking in vivo using magnetic resonance imaging (MRI) is an emerging hot topic garnering ever increasing attention, yet it is fraught with numerous methodological challenges, which merit careful attention. Several of the current procedures used to label cells for tracking by MRI take advantage of the intrinsic phagocytic nature of cells to engulf nanoparticles, though cells with low intrinsic phagocytic capacity are also commonly studied. Before we take the next steps towards administering such cells in vivo, it is essential to understand how the nanolabel is recognized, internalized, trafficked and distributed within the specific host cell. This is even more critical when contemplating labeling of cells that may ultimately be applied in vivo to patients in a therapeutic context.

    Original languageEnglish
    Pages (from-to)e1345403
    JournalOncoImmunology
    Volume6
    Issue number10
    Early online date20 Jul 2017
    DOIs
    Publication statusE-pub ahead of print - 20 Jul 2017

    Keywords

    • Journal Article

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