Lack of a significant effect of deletion of the tachykinin neurokinin-1 receptor on wound healing in mouse skin

T Cao, A D Grant, N P Gerard, S D Brain

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The tachykinin neurokinin-1 (NK(1)) receptor mediates the vasoactive effects of substance P and related members of the tachykinin family. Substance P acts via the NK(1) receptor to mediate increased microvascular permeability leading to oedema formation as confirmed in NK(1) receptor knockout mice. In addition there is evidence that neuropeptides such as substance P can have a modulatory effect on the wound-healing process. In this study male and female wild-type and NK(1) knockout mice were investigated for their comparative ability to induce acute oedema formation in response to topical application of capsaicin, as measured by the extravasation of intravenous radiolabelled-albumin, and wound healing in response to a cut, as measured by area of wound over the following days.Significant (P
Original languageEnglish
Pages (from-to)695 - 700
Number of pages6
JournalNeuroscience
Volume108
Issue number4
DOIs
Publication statusPublished - 18 Dec 2001

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