Lack of association between TDP-43 pathology and tau mis-splicing in Alzheimer's disease

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Abstract

A proportion of Alzheimer's disease cases displays inclusions of the RNA-binding protein, TDP-43. Considering the pathogenic role of tau mis-splicing, we compared tau isoform expression between Alzheimer's disease cases with or without TDP-43 inclusions. The average ratio of tau isoforms containing or lacking exon 10 (4R/3R ratio) or the total level of tau mRNA was not significantly different between cases with or without TDP-43 pathology in any of the brain regions examined. Although TDP-43 functions may be affected, TDP-43 does not critically regulate expression or splicing of tau in Alzheimer's disease suggesting that TDP-43 contributes to Alzheimer's disease through mechanisms independent of tau.

Original languageEnglish
Pages (from-to)45-46
Number of pages2
JournalNeurobiology of Aging
Volume37
Early online date9 Oct 2015
DOIs
Publication statusPublished - 1 Jan 2016

Keywords

  • Alzheimer's disease
  • Splicing
  • Tau
  • Tauopathy
  • TDP-43

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