Lack of effect of Maraviroc intensification on blood and gut reservoir

Juan Tiraboschi; Shuvra Ray; Kamal Patel; Matthew Pace; Prabhjeet Phalora; Nicola Robinson; Emily Hopkins; Jodi Meyerowitz; Yanzhong Wang; Olubanke Davies; Christine Mant; John Cason; Steve Kaye; Jeremy Sanderson; Sara Fidler; Paul Klenerman; John Frater; Julie Fox

doi:10.1089/aid.2016.0198

Lack of effect of Maraviroc intensification on blood and gut reservoir

Juan Tiraboschi, Shuvra Ray, Kamal Patel, Matthew Pace, Prabhjeet Phalora, Nicola Robinson, Emily Hopkins, Jodi Meyerowitz, Yanzhong Wang, Olubanke Davies, Christine Mant, John Cason, Steve Kaye, Jeremy Sanderson, Sara Fidler, Paul Klenerman, John Frater, Julie Fox

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Abstract

We show that intensification of treatment with maraviroc in patients chronically infected with HIV-1 receiving successful long-term ART was not associated with improvements in HIV related morbidity, HIV reservoir, microbial translocation, immune activation or immune exhaustion in either gut or peripheral blood. The measurement of reservoir in both gut and blood longitudinally contributes to a paucity of data in the area.

Original language	English
Pages (from-to)	143-146
Journal	Aids Research and Human Retroviruses
Volume	33
Issue number	2
Early online date	4 Dec 2016
DOIs	https://doi.org/10.1089/aid.2016.0198
Publication status	Published - 1 Feb 2017

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10.1089/aid.2016.0198

Lack of effect of Maraviroc_TIRABOSCHI_Firstonline4December2016_GREEN AAM
Final publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/AID.2016.0198”
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Tiraboschi, J., Ray, S., Patel, K., Pace, M., Phalora, P., Robinson, N., Hopkins, E., Meyerowitz, J., Wang, Y., Davies, O., Mant, C., Cason, J., Kaye, S., Sanderson, J., Fidler, S., Klenerman, P., Frater, J., & Fox, J. (2017). Lack of effect of Maraviroc intensification on blood and gut reservoir. Aids Research and Human Retroviruses, 33(2), 143-146. https://doi.org/10.1089/aid.2016.0198

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Tiraboschi, J, Ray, S, Patel, K, Pace, M, Phalora, P, Robinson, N, Hopkins, E, Meyerowitz, J, Wang, Y, Davies, O, Mant, C , Cason, J, Kaye, S, Sanderson, J, Fidler, S, Klenerman, P, Frater, J & Fox, J 2017, 'Lack of effect of Maraviroc intensification on blood and gut reservoir', Aids Research and Human Retroviruses, vol. 33, no. 2, pp. 143-146. https://doi.org/10.1089/aid.2016.0198

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T1 - Lack of effect of Maraviroc intensification on blood and gut reservoir

AU - Tiraboschi, Juan

AU - Ray, Shuvra

AU - Patel, Kamal

AU - Pace, Matthew

AU - Phalora, Prabhjeet

AU - Robinson, Nicola

AU - Hopkins, Emily

AU - Meyerowitz, Jodi

AU - Wang, Yanzhong

AU - Davies, Olubanke

AU - Mant, Christine

AU - Cason, John

AU - Kaye, Steve

AU - Sanderson, Jeremy

AU - Fidler, Sara

AU - Klenerman, Paul

AU - Frater, John

AU - Fox, Julie

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AB - We show that intensification of treatment with maraviroc in patients chronically infected with HIV-1 receiving successful long-term ART was not associated with improvements in HIV related morbidity, HIV reservoir, microbial translocation, immune activation or immune exhaustion in either gut or peripheral blood. The measurement of reservoir in both gut and blood longitudinally contributes to a paucity of data in the area.

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DO - 10.1089/aid.2016.0198

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JO - Aids Research and Human Retroviruses

JF - Aids Research and Human Retroviruses

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ER -

Lack of effect of Maraviroc intensification on blood and gut reservoir

Abstract

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