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Lack of effect of Maraviroc intensification on blood and gut reservoir

Research output: Contribution to journalArticlepeer-review

Juan Tiraboschi, Shuvra Ray, Kamal Patel, Matthew Pace, Prabhjeet Phalora, Nicola Robinson, Emily Hopkins, Jodi Meyerowitz, Yanzhong Wang, Olubanke Davies, Christine Mant, John Cason, Steve Kaye, Jeremy Sanderson, Sara Fidler, Paul Klenerman, John Frater, Julie Fox

Original languageEnglish
Pages (from-to)143-146
JournalAids Research and Human Retroviruses
Volume33
Issue number2
Early online date4 Dec 2016
DOIs
E-pub ahead of print4 Dec 2016
Published1 Feb 2017

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King's Authors

Abstract

We show that intensification of treatment with maraviroc in patients chronically infected with HIV-1 receiving successful long-term ART was not associated with improvements in HIV related morbidity, HIV reservoir, microbial translocation, immune activation or immune exhaustion in either gut or peripheral blood. The measurement of reservoir in both gut and blood longitudinally contributes to a paucity of data in the area.

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