Lack of periosteal apposition in the head and neck of femur after menopause in Chinese women with high risk for hip fractures — A cross-sectional study with QCT

Yongbin Su, Ling Wang*, Xiaoyan Liu, Minghui Yang, Chen Yi, Yandong Liu, Pengju Huang, Zhe Guo, Aihong Yu, Xiaoguang Cheng, Xinbao Wu, Glen M. Blake, Klaus Engelke

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    In elderly subjects and in particular in those with osteoporosis the evidence on age related volume changes of the hip is still very limited. Even less is known about bone changes of the femoral head. The aim of this study is to explore associations of bone size of the femoral head and neck with age in postmenopausal women with very high risk of hip fracture and to investigate associations of femoral head and neck bone mineral density. MIAF (medical image analysis framework)-Femur was used for the analysis of CT datasets from 319 females with acute hip fractures age 50 to 98. Integral BMD and volume of the head and neck were assessed. The femoral head was divided into four quadrants to address differential vBMD and volume responses of its superior, inferior, posterior and anterior parts. Areal BMD (aBMD) of femoral neck was also obtained. In this population of postmenopausal women we did not observe age-related changes in bone volume of the femoral head or neck between ages 50 and 98 years. Integral vBMD in the head in the 90–98 year group was 48.0 mg/cm3 lower than that in 50–59 year group, which accounts for nearly 30% decrease in vBMD with 40 years increase. Age-related vBMD changes in the head quadrants were similar to that in total. With age, the trend line correlation coefficients for vBMD in quadrants were relatively small, but significant (p < 0.001) for all. The femoral head integral vBMD correlates well with neck vBMD and FN aBMD. FN aBMD explained 45% of head integral vBMD variance (p < 0.0001). Elderly women had relative preservation of femoral head and neck bone volume from 50 yrs. over four decades but markedly lower integral vBMD of proximal femur. The findings of our study call in question about the concept of bone expansion with aging even in elderly age.

    Original languageEnglish
    Article number115545
    JournalBone
    Volume139
    DOIs
    Publication statusPublished - Oct 2020

    Keywords

    • Age
    • Femoral head
    • Femoral neck
    • Hip fracture
    • Quantitative computed tomography

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