Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

TY - JOUR

T1 - Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

AU - Pettigrew, K. A.

AU - Fajutrao Valles, S. F.

AU - Moll, K.

AU - Northstone, K.

AU - Ring, S.

AU - Pennell, C.

AU - Wang, C.

AU - Leavett, R.

AU - Hayiou-Thomas, M. E.

AU - Thompson, P.

AU - Simpson, N. H.

AU - Fisher, S. E.

AU - Newbury, D. F.

AU - Nudel, R.

AU - Monaco, A. P.

AU - Francks, C.

AU - Baird, G.

AU - Slonims, V.

AU - Dworzynski, K.

AU - Bolton, P. F.

AU - Simonoff, E.

AU - O'Hare, A.

AU - Seckl, J.

AU - Cowie, H.

AU - Clark, A.

AU - Watson, J.

AU - Nasir, J.

AU - Cohen, W.

AU - Everitt, A.

AU - Hennessy, E. R.

AU - Shaw, D.

AU - Helms, P. J.

AU - Simkin, Z.

AU - Conti, G.

AU - Ramsden, D.

AU - Bishop, D. V M

AU - Pickles, A.

AU - Whitehouse, A. J O

AU - Snowling, M. J.

AU - Paracchini, S.

AU - The SLI Consortium, SLI Consortium

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N=3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities.

AB - Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N=3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities.

KW - ALSPAC

KW - Cognitive abilities

KW - Dyscalculia

KW - Dyslexia

KW - Genetic association

KW - Neurodevelopmental disorders

UR - http://www.scopus.com/inward/record.url?scp=84928304900&partnerID=8YFLogxK

U2 - 10.1111/gbb.12213

DO - 10.1111/gbb.12213

M3 - Article

AN - SCOPUS:84928304900

SN - 1601-1848

VL - 14

SP - 369

EP - 376

JO - Genes, Brain and Behavior

JF - Genes, Brain and Behavior

IS - 4

ER -