King's College London

Research portal

Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

Research output: Contribution to journalArticle

K. A. Pettigrew, S. F. Fajutrao Valles, K. Moll, K. Northstone, S. Ring, C. Pennell, C. Wang, R. Leavett, M. E. Hayiou-Thomas, P. Thompson, N. H. Simpson, S. E. Fisher, D. F. Newbury, R. Nudel, A. P. Monaco, C. Francks, G. Baird, V. Slonims, K. Dworzynski, P. F. Bolton & 21 more E. Simonoff, A. O'Hare, J. Seckl, H. Cowie, A. Clark, J. Watson, J. Nasir, W. Cohen, A. Everitt, E. R. Hennessy, D. Shaw, P. J. Helms, Z. Simkin, G. Conti, D. Ramsden, D. V M Bishop, A. Pickles, A. J O Whitehouse, M. J. Snowling, S. Paracchini, SLI Consortium The SLI Consortium

Original languageEnglish
Pages (from-to)369-376
Number of pages8
JournalGenes, Brain and Behavior
Volume14
Issue number4
DOIs
Publication statusPublished - 1 Apr 2015

Documents

King's Authors

Abstract

Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N=3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities.

Download statistics

No data available

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454