King's College London

Research portal

Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton

Research output: Contribution to journalArticle

Standard

Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton. / Skuntz, Susan; Mankoo, Baljinder; Nguyen, Minh-Thanh T.; Hustert, Elisabeth; Nakayama, Atsuo; Tournier-Lasserve, Elisabeth; Wright, Christopher V. E.; Pachnis, Vassilis; Bharti, Kapil; Arnheiter, Heinz.

In: Developmental Biology, Vol. 332, No. 2, 15.08.2009, p. 383 - 395.

Research output: Contribution to journalArticle

Harvard

Skuntz, S, Mankoo, B, Nguyen, M-TT, Hustert, E, Nakayama, A, Tournier-Lasserve, E, Wright, CVE, Pachnis, V, Bharti, K & Arnheiter, H 2009, 'Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton', Developmental Biology, vol. 332, no. 2, pp. 383 - 395. https://doi.org/10.1016/j.ydbio.2009.06.006

APA

Skuntz, S., Mankoo, B., Nguyen, M-T. T., Hustert, E., Nakayama, A., Tournier-Lasserve, E., ... Arnheiter, H. (2009). Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton. Developmental Biology, 332(2), 383 - 395. https://doi.org/10.1016/j.ydbio.2009.06.006

Vancouver

Skuntz S, Mankoo B, Nguyen M-TT, Hustert E, Nakayama A, Tournier-Lasserve E et al. Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton. Developmental Biology. 2009 Aug 15;332(2):383 - 395. https://doi.org/10.1016/j.ydbio.2009.06.006

Author

Skuntz, Susan ; Mankoo, Baljinder ; Nguyen, Minh-Thanh T. ; Hustert, Elisabeth ; Nakayama, Atsuo ; Tournier-Lasserve, Elisabeth ; Wright, Christopher V. E. ; Pachnis, Vassilis ; Bharti, Kapil ; Arnheiter, Heinz. / Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton. In: Developmental Biology. 2009 ; Vol. 332, No. 2. pp. 383 - 395.

Bibtex Download

@article{a25bd1d6ecfc45e5b6269ac13128c04f,
title = "Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton",
abstract = "Meox1 and Meox2 are two related homeodomain transcription factor genes that together are essential for the development of all somite compartments. Here we show that mice homozygous for Meox1 mutations alone have abnormalities that are restricted to the sclerotome and its derivatives. A prominent and consistent phenotype of these mutations is a remodeling of the cranio-cervical joints whose major feature is the assimilation of the atlas into the basioccipital bone so that the skull rests on the axis. These abnormalities can be traced back to changes in the relative rates of cell proliferation in the rostral and caudal sclerotome compartments, and they are associated with alterations in the expression of at least three transcription factor genes, Tbx18, Uncx, and Bapx1. As previously observed for Bapx1, MEOX1 protein occupies evolutionarily conserved promoter regions of Tbx18 and Uncx, suggesting that Meox1 regulates these genes at least in part directly. Hence, Meox1 is part of a regulatory circuit that serves an essential, non-redundant function in the maintenance of rostro-caudal sclerotome polarity and axial skeleton formation. (C) Published by Elsevier Inc.",
author = "Susan Skuntz and Baljinder Mankoo and Nguyen, {Minh-Thanh T.} and Elisabeth Hustert and Atsuo Nakayama and Elisabeth Tournier-Lasserve and Wright, {Christopher V. E.} and Vassilis Pachnis and Kapil Bharti and Heinz Arnheiter",
year = "2009",
month = "8",
day = "15",
doi = "10.1016/j.ydbio.2009.06.006",
language = "English",
volume = "332",
pages = "383 -- 395",
journal = "Developmental Biology",
issn = "0012-1606",
publisher = "Elsevier Inc.",
number = "2",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton

AU - Skuntz, Susan

AU - Mankoo, Baljinder

AU - Nguyen, Minh-Thanh T.

AU - Hustert, Elisabeth

AU - Nakayama, Atsuo

AU - Tournier-Lasserve, Elisabeth

AU - Wright, Christopher V. E.

AU - Pachnis, Vassilis

AU - Bharti, Kapil

AU - Arnheiter, Heinz

PY - 2009/8/15

Y1 - 2009/8/15

N2 - Meox1 and Meox2 are two related homeodomain transcription factor genes that together are essential for the development of all somite compartments. Here we show that mice homozygous for Meox1 mutations alone have abnormalities that are restricted to the sclerotome and its derivatives. A prominent and consistent phenotype of these mutations is a remodeling of the cranio-cervical joints whose major feature is the assimilation of the atlas into the basioccipital bone so that the skull rests on the axis. These abnormalities can be traced back to changes in the relative rates of cell proliferation in the rostral and caudal sclerotome compartments, and they are associated with alterations in the expression of at least three transcription factor genes, Tbx18, Uncx, and Bapx1. As previously observed for Bapx1, MEOX1 protein occupies evolutionarily conserved promoter regions of Tbx18 and Uncx, suggesting that Meox1 regulates these genes at least in part directly. Hence, Meox1 is part of a regulatory circuit that serves an essential, non-redundant function in the maintenance of rostro-caudal sclerotome polarity and axial skeleton formation. (C) Published by Elsevier Inc.

AB - Meox1 and Meox2 are two related homeodomain transcription factor genes that together are essential for the development of all somite compartments. Here we show that mice homozygous for Meox1 mutations alone have abnormalities that are restricted to the sclerotome and its derivatives. A prominent and consistent phenotype of these mutations is a remodeling of the cranio-cervical joints whose major feature is the assimilation of the atlas into the basioccipital bone so that the skull rests on the axis. These abnormalities can be traced back to changes in the relative rates of cell proliferation in the rostral and caudal sclerotome compartments, and they are associated with alterations in the expression of at least three transcription factor genes, Tbx18, Uncx, and Bapx1. As previously observed for Bapx1, MEOX1 protein occupies evolutionarily conserved promoter regions of Tbx18 and Uncx, suggesting that Meox1 regulates these genes at least in part directly. Hence, Meox1 is part of a regulatory circuit that serves an essential, non-redundant function in the maintenance of rostro-caudal sclerotome polarity and axial skeleton formation. (C) Published by Elsevier Inc.

U2 - 10.1016/j.ydbio.2009.06.006

DO - 10.1016/j.ydbio.2009.06.006

M3 - Article

VL - 332

SP - 383

EP - 395

JO - Developmental Biology

JF - Developmental Biology

SN - 0012-1606

IS - 2

ER -

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454