Language ability in preterm children is associated with arcuate fasciculi microstructure at term

Piergiorgio Salvan, J Donald Tournier, Dafnis Batalle, Shona Falconer, Andrew Chew, Nigel Kennea, Paul Aljabar, Ghislaine Dehaene-Lambertz, Tomoki Arichi, A David Edwards*, Serena J Counsell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)
190 Downloads (Pure)

Abstract

In the mature human brain, the arcuate fasciculus mediates verbal working memory, word learning, and sublexical speech repetition. However, its contribution to early language acquisition remains unclear. In this work, we aimed to evaluate the role of the direct segments of the arcuate fasciculi in the early acquisition of linguistic function. We imaged a cohort of 43 preterm born infants (median age at birth of 30 gestational weeks; median age at scan of 42 postmenstrual weeks) using high b value high-angular resolution diffusion-weighted neuroimaging and assessed their linguistic performance at 2 years of age. Using constrained spherical deconvolution tractography, we virtually dissected the arcuate fasciculi and measured fractional anisotropy (FA) as a metric of white matter development. We found that term equivalent FA of the left and right arcuate fasciculi was significantly associated with individual differences in linguistic and cognitive abilities in early childhood, independent of the degree of prematurity. These findings suggest that differences in arcuate fasciculi microstructure at the time of normal birth have a significant impact on language development and modulate the first stages of language learning.

Original languageEnglish
Pages (from-to)3836-3847
JournalHuman Brain Mapping
Volume38
Issue number8
Early online date4 May 2017
DOIs
Publication statusPublished - 5 Jul 2017

Keywords

  • Brain
  • Diffusion magnetic resonance imaging
  • Infant
  • Language development
  • Preterm birth

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