TY - JOUR
T1 - Large-scale digital phenotyping
T2 - Identifying depression and anxiety indicators in a general UK population with over 10,000 participants
AU - Zhang, Yuezhou
AU - Stewart, Callum
AU - Ranjan, Yatharth
AU - Conde, Pauline
AU - Sankesara, Heet
AU - Rashid, Zulqarnain
AU - Sun, Shaoxiong
AU - Dobson, Richard J.B.
AU - Folarin, Amos A.
N1 - Publisher Copyright:
© 2025 The Authors
PY - 2025/4/15
Y1 - 2025/4/15
N2 - Background: Digital phenotyping offers a novel and cost-efficient approach for managing depression and anxiety. Previous studies, often limited to small-to-medium or specific populations, may lack generalizability. Methods: We conducted a cross-sectional analysis of data from 10,129 participants recruited from a UK-based general population between June 2020 and August 2022. Participants shared wearable (Fitbit) data and self-reported questionnaires on depression, anxiety, and mood via a study app. We examined correlations between mental health scores and wearable-derived features, demographics, health variables, and mood assessments. Unsupervised clustering was used to identify behavioural patterns associated with depression and anxiety. Furthermore, we employed XGBoost machine learning models to predict depression and anxiety severity and compared the performance using different subsets of features. Results: We observed significant associations between the severity of depression and anxiety with several factors, including mood, age, gender, BMI, sleep patterns, physical activity, and heart rate. Clustering analysis revealed that participants simultaneously exhibiting lower physical activity levels and higher heart rates reported more severe symptoms. Prediction models incorporating all types of variables achieved the best performance (R2 = 0.41, MAE = 3.42 for depression; R2 = 0.31, MAE = 3.50 for anxiety) compared to those using subsets of variables. Several wearable-derived features were observed to have non-linear relationships with depression and anxiety in the prediction models. Limitations: Data collection during the COVID-19 pandemic may introduce biases. Conclusion: This study identified several indicators for depression and anxiety and highlighted the potential of digital phenotyping and machine learning technologies for rapid screening of mental disorders in general populations.
AB - Background: Digital phenotyping offers a novel and cost-efficient approach for managing depression and anxiety. Previous studies, often limited to small-to-medium or specific populations, may lack generalizability. Methods: We conducted a cross-sectional analysis of data from 10,129 participants recruited from a UK-based general population between June 2020 and August 2022. Participants shared wearable (Fitbit) data and self-reported questionnaires on depression, anxiety, and mood via a study app. We examined correlations between mental health scores and wearable-derived features, demographics, health variables, and mood assessments. Unsupervised clustering was used to identify behavioural patterns associated with depression and anxiety. Furthermore, we employed XGBoost machine learning models to predict depression and anxiety severity and compared the performance using different subsets of features. Results: We observed significant associations between the severity of depression and anxiety with several factors, including mood, age, gender, BMI, sleep patterns, physical activity, and heart rate. Clustering analysis revealed that participants simultaneously exhibiting lower physical activity levels and higher heart rates reported more severe symptoms. Prediction models incorporating all types of variables achieved the best performance (R2 = 0.41, MAE = 3.42 for depression; R2 = 0.31, MAE = 3.50 for anxiety) compared to those using subsets of variables. Several wearable-derived features were observed to have non-linear relationships with depression and anxiety in the prediction models. Limitations: Data collection during the COVID-19 pandemic may introduce biases. Conclusion: This study identified several indicators for depression and anxiety and highlighted the potential of digital phenotyping and machine learning technologies for rapid screening of mental disorders in general populations.
KW - Anxiety
KW - Depression
KW - Digital phenotyping
KW - Machine learning
KW - Mobile health (mHealth)
KW - Wearable devices
UR - http://www.scopus.com/inward/record.url?scp=85216446966&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2025.01.124
DO - 10.1016/j.jad.2025.01.124
M3 - Article
C2 - 39892753
AN - SCOPUS:85216446966
SN - 0165-0327
VL - 375
SP - 412
EP - 422
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -