LARP4A and LARP4B in cancer: The new kids on the block

Research output: Contribution to journalShort surveypeer-review

Abstract

Recent developments have mounted a stunning body of evidence underlying the importance of RNA binding proteins (RBPs) in cancer research. In this minireview we focus on LARP4A and LARP4B, two paralogs belonging to the superfamily of La-related proteins, and provide a critical overview of current research, including their roles in cancer pathogenesis and cell proliferation, migration, cell cycle and apoptosis. We highlight current controversies surrounding LARP4A and LARP4B and conclude that their complex roles in tumorigenesis are cell-, tissue- and context-dependent, warning that caution must be exercised before categorising either protein as an oncoprotein or tumour-suppressor. We also reveal that LARP4A and LARP4B have often been confused with one another, adding uncertainty in delineating their functions. We suggest that further functional and mechanistic studies of LARP4 proteins present significant challenges for future investigations to recognise the vital contributions of these RBPs in cancer research.

Original languageEnglish
Article number106441
JournalInternational Journal of Biochemistry and Cell Biology
Volume161
DOIs
Publication statusPublished - Aug 2023

Keywords

  • Cancer
  • LARP4
  • LARP4A
  • LARP4B
  • RNA-binding proteins

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