Laser Therapy Inhibits Tumor Growth in Mice by Promoting Immune Surveillance and Vessel Normalization

Giulia Ottaviani; Valentina Martinelli; Katia Rupel; Nicoletta Caronni; Asma Naseem; Lorenzo Zandonà; Giuseppe Perinetti; Margherita Gobbo; Roberto Di Lenarda; Rossana Bussani; Federica Benvenuti; Mauro Giacca; Matteo Biasotto; Serena Zacchigna

doi:10.1016/j.ebiom.2016.07.028

Laser Therapy Inhibits Tumor Growth in Mice by Promoting Immune Surveillance and Vessel Normalization

Giulia Ottaviani
, Valentina Martinelli
, Katia Rupel
, Nicoletta Caronni
, Asma Naseem
, Lorenzo Zandonà
, Giuseppe Perinetti
, Margherita Gobbo
, Roberto Di Lenarda
, Rossana Bussani
, Federica Benvenuti
, Mauro Giacca
, Matteo Biasotto
, Serena Zacchigna^*

^*Corresponding author for this work

Cardiovascular Medicine & Sciences

Azienda Sanitaria Universitaria Integrata di Trieste
International Centre for Genetic Engineering and Biotechnology
Department of Medical

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

Laser therapy, recently renamed as photobiomodulation, stands as a promising supportive treatment for oral mucositis induced by oncological therapies. However, its mechanisms of action and, more importantly, its safety in cancer patients, are still unclear. Here we explored the anti-cancer effect of 3 laser protocols, set at the most commonly used wavelengths, in B16F10 melanoma and oral carcinogenesis mouse models. While laser light increased cell metabolism in cultured cells, the in vivo outcome was reduced tumor progression. This striking, unexpected result, was paralleled by the recruitment of immune cells, in particular T lymphocytes and dendritic cells, which secreted type I interferons. Laser light also reduced the number of highly angiogenic macrophages within the tumor mass and promoted vessel normalization, an emerging strategy to control tumor progression. Collectively, these results set photobiomodulation as a safety procedure in oncological patients and open the way to its innovative use for cancer therapy.

Original language	English
Pages (from-to)	165-172
Number of pages	8
Journal	EBioMedicine
Volume	11
DOIs	https://doi.org/10.1016/j.ebiom.2016.07.028
Publication status	Published - 1 Sept 2016

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SDG 3 Good Health and Well-being

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10.1016/j.ebiom.2016.07.028

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Ottaviani, G., Martinelli, V., Rupel, K., Caronni, N., Naseem, A., Zandonà, L., Perinetti, G., Gobbo, M., Di Lenarda, R., Bussani, R., Benvenuti, F., Giacca, M., Biasotto, M., & Zacchigna, S. (2016). Laser Therapy Inhibits Tumor Growth in Mice by Promoting Immune Surveillance and Vessel Normalization. EBioMedicine, 11, 165-172. https://doi.org/10.1016/j.ebiom.2016.07.028

@article{b87fd29233c84faa80ab57e993e97f8a,

title = "Laser Therapy Inhibits Tumor Growth in Mice by Promoting Immune Surveillance and Vessel Normalization",

abstract = "Laser therapy, recently renamed as photobiomodulation, stands as a promising supportive treatment for oral mucositis induced by oncological therapies. However, its mechanisms of action and, more importantly, its safety in cancer patients, are still unclear. Here we explored the anti-cancer effect of 3 laser protocols, set at the most commonly used wavelengths, in B16F10 melanoma and oral carcinogenesis mouse models. While laser light increased cell metabolism in cultured cells, the in vivo outcome was reduced tumor progression. This striking, unexpected result, was paralleled by the recruitment of immune cells, in particular T lymphocytes and dendritic cells, which secreted type I interferons. Laser light also reduced the number of highly angiogenic macrophages within the tumor mass and promoted vessel normalization, an emerging strategy to control tumor progression. Collectively, these results set photobiomodulation as a safety procedure in oncological patients and open the way to its innovative use for cancer therapy.",

author = "Giulia Ottaviani and Valentina Martinelli and Katia Rupel and Nicoletta Caronni and Asma Naseem and Lorenzo Zandon{\`a} and Giuseppe Perinetti and Margherita Gobbo and \{Di Lenarda\}, Roberto and Rossana Bussani and Federica Benvenuti and Mauro Giacca and Matteo Biasotto and Serena Zacchigna",

year = "2016",

month = sep,

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doi = "10.1016/j.ebiom.2016.07.028",

language = "English",

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T1 - Laser Therapy Inhibits Tumor Growth in Mice by Promoting Immune Surveillance and Vessel Normalization

AU - Ottaviani, Giulia

AU - Martinelli, Valentina

AU - Rupel, Katia

AU - Caronni, Nicoletta

AU - Naseem, Asma

AU - Zandonà, Lorenzo

AU - Perinetti, Giuseppe

AU - Gobbo, Margherita

AU - Di Lenarda, Roberto

AU - Bussani, Rossana

AU - Benvenuti, Federica

AU - Giacca, Mauro

AU - Biasotto, Matteo

AU - Zacchigna, Serena

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Laser therapy, recently renamed as photobiomodulation, stands as a promising supportive treatment for oral mucositis induced by oncological therapies. However, its mechanisms of action and, more importantly, its safety in cancer patients, are still unclear. Here we explored the anti-cancer effect of 3 laser protocols, set at the most commonly used wavelengths, in B16F10 melanoma and oral carcinogenesis mouse models. While laser light increased cell metabolism in cultured cells, the in vivo outcome was reduced tumor progression. This striking, unexpected result, was paralleled by the recruitment of immune cells, in particular T lymphocytes and dendritic cells, which secreted type I interferons. Laser light also reduced the number of highly angiogenic macrophages within the tumor mass and promoted vessel normalization, an emerging strategy to control tumor progression. Collectively, these results set photobiomodulation as a safety procedure in oncological patients and open the way to its innovative use for cancer therapy.

AB - Laser therapy, recently renamed as photobiomodulation, stands as a promising supportive treatment for oral mucositis induced by oncological therapies. However, its mechanisms of action and, more importantly, its safety in cancer patients, are still unclear. Here we explored the anti-cancer effect of 3 laser protocols, set at the most commonly used wavelengths, in B16F10 melanoma and oral carcinogenesis mouse models. While laser light increased cell metabolism in cultured cells, the in vivo outcome was reduced tumor progression. This striking, unexpected result, was paralleled by the recruitment of immune cells, in particular T lymphocytes and dendritic cells, which secreted type I interferons. Laser light also reduced the number of highly angiogenic macrophages within the tumor mass and promoted vessel normalization, an emerging strategy to control tumor progression. Collectively, these results set photobiomodulation as a safety procedure in oncological patients and open the way to its innovative use for cancer therapy.

UR - https://www.scopus.com/pages/publications/84994804543

U2 - 10.1016/j.ebiom.2016.07.028

DO - 10.1016/j.ebiom.2016.07.028

M3 - Article

C2 - 27475897

AN - SCOPUS:84994804543

SN - 2352-3964

VL - 11

SP - 165

EP - 172

JO - EBioMedicine

JF - EBioMedicine

ER -

Laser Therapy Inhibits Tumor Growth in Mice by Promoting Immune Surveillance and Vessel Normalization

Abstract

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