TY - JOUR
T1 - Latest advances in imaging oxidative stress in cancer
AU - Greenwood, Hannah E
AU - Witney, Timothy H
N1 - Funding Information:
This research was funded in whole, or in part, by the Wellcome Trust (senior research fellowship 220221/Z/20/Z to Timothy Witney and Wellcome/EPSRC Centre for Medical Engineering grant WT203148/Z/16/Z to Hannah Greenwood). No other potential conflict of interest relevant to this article was reported.
Publisher Copyright:
© 2021 Society of Nuclear Medicine Inc.. All rights reserved.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Oxidative stress is the imbalance of harmful reactive oxygen species (ROS) and the action of neutralizing antioxidant mechanisms. If left unchecked, the deleterious effects of oxidative stress result in damage to DNA, proteins, and membranes, ultimately leading to cell death. Tumors are highly proliferative and consequently generate high levels of mitochondrial ROS. To compensate for this and maintain redox homeostasis, cancer cells upregulate protective antioxidant pathways, which are further amplified in drug-resistant tumors. This review provides an overview of the latest molecular imaging techniques designed to image oxidative stress in cancer. New probes can now assess heterogeneous ROS and antioxidant production within tumors and across lesions. Together, the noninvasive imaging of these dynamic processes holds great promise for monitoring response to treatment and predicting drug resistance and may provide insight into the metastatic potential of tumors.
AB - Oxidative stress is the imbalance of harmful reactive oxygen species (ROS) and the action of neutralizing antioxidant mechanisms. If left unchecked, the deleterious effects of oxidative stress result in damage to DNA, proteins, and membranes, ultimately leading to cell death. Tumors are highly proliferative and consequently generate high levels of mitochondrial ROS. To compensate for this and maintain redox homeostasis, cancer cells upregulate protective antioxidant pathways, which are further amplified in drug-resistant tumors. This review provides an overview of the latest molecular imaging techniques designed to image oxidative stress in cancer. New probes can now assess heterogeneous ROS and antioxidant production within tumors and across lesions. Together, the noninvasive imaging of these dynamic processes holds great promise for monitoring response to treatment and predicting drug resistance and may provide insight into the metastatic potential of tumors.
UR - http://www.scopus.com/inward/record.url?scp=85119612401&partnerID=8YFLogxK
U2 - 10.2967/jnumed.120.256974
DO - 10.2967/jnumed.120.256974
M3 - Article
C2 - 34353871
SN - 1535-5667
VL - 62
SP - 1506
EP - 1510
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
IS - 11
ER -
