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LC-MS in analytical toxicology: some practical considerations

Research output: Contribution to journalLiterature reviewpeer-review

Original languageEnglish
Pages (from-to)100 - 123
Number of pages24
JournalBiomedical Chromatography
Issue number1-2
PublishedJan 2011

King's Authors


Liquid chromatography, coupled with single-stage or tandem mass spectrometry, is a powerful tool increasingly used in analytical toxicology. However, the atmospheric pressure ionization processes involved are complex, and subject to interference from matrix components, for example. Further, the techniques used in sample preparation, chromatography and mass analysis are developing rapidly. An understanding of the advantages and limitations of LC-MS ensures appropriate analyses are performed, and that reliable results are generated. Consideration should be given to the influence of the sample preparation and chromatographic conditions on the ionization of the analyte at the mass spectrometer interface. This review aims to provide some practical guidance and examples to aid method development for commonly encountered analytes in analytical toxicology.

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