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Le peptide vasoactif intestinal: un nouveau facteur neurotrophique

Research output: Contribution to journalArticle

P Gressens, Pierre Gressens

Original languageFrench
Pages (from-to)654-60
Number of pages7
JournalArchives De Pediatrie
Issue number6
Publication statusPublished - Jun 1998

King's Authors


Vasoactive intestinal peptide (VIP) is a 28-amino acid neuropeptide with potent growth-related actions on dissociated neural cells. In recent years its role in brain development has been elucidated: VIP has been shown to be a regulator of early neurodevelopment and embryonic growth, a stimulator of neocortical astrocytogenesis and a neuroprotective molecule against excitotoxic and other neurotoxic substances. Thus VIP appears as a fundamental regulator of brain growth and development, and a potent neuroprotective agent, possibly involved in pathological processes such as microcephalies and some neurological impairments observed in very premature babies. Similarly, VIP and VIP derivatives could represent a new avenue in the search of therapeutics for excitotoxic lesions of the developing brain.

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