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Learning and combining image similarities for neonatal brain population studies

Research output: Chapter in Book/Report/Conference proceedingConference paper

Veronika A. Zimmer, Ben Glocker, Paul Aljabar, Serena Counsell, Mary Rutherford, A. David Edwards, Jo V. Hajnal, Miguel Ángel González Ballester, Daniel Rueckert, Gemma Piella

Original languageEnglish
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
PublisherSpringer-Verlag Berlin Heidelberg
Pages110-117
Number of pages8
Volume9352
ISBN (Print)9783319248875
DOIs
Publication statusPublished - 2 Oct 2015
Event6th International Workshop on Machine Learning in Medical Imaging, MLMI 2015 and Held in Conjunction with 18th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2015 - Munich, Germany
Duration: 5 Oct 20155 Oct 2015

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9352
ISSN (Print)03029743
ISSN (Electronic)16113349

Conference

Conference6th International Workshop on Machine Learning in Medical Imaging, MLMI 2015 and Held in Conjunction with 18th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2015
CountryGermany
CityMunich
Period5/10/20155/10/2015

King's Authors

Abstract

The characterization of neurodevelopment is challenging due to the complex structural changes of the brain in early childhood. To analyze the changes in a population across time and to relate them with clinical information, manifold learning techniques can be applied. The neighborhood definition used for constructing manifold representations of the population is crucial for preserving the similarity structure in the embedding and highly application dependent. It has been shown that the combination of several notions of similarity and features can improve the new representation. However, how to combine and weight different similarites and features is non-trivial. In this work, we propose to learn the neighborhood structure and similarity measure used for manifold learning through Neighborhood Approximation Forests (NAFs). The recently proposed NAFs learn a neighborhood structure in a dataset based on a user-defined distance. A characterization of image similarity using NAFs enables us to construct manifold representations based on a previously defined criterion to improve predictions regarding structural and clinical information. In particular, NAFs can be used naturally to combine the affinities learned from multiple distances in a joint manifold towards a more meaningful representation and an improved characterization of the resulting embedding. We demonstrate the utility of NAFs in manifold learning on a population of preterm and in term neonates for classification regarding structural volume and clinical information.

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