@inbook{a76fa8c0803745bc91331aad692bfa0d,
title = "Left Atrial Ejection Fraction Estimation Using SEGANet for Fully Automated Segmentation of CINE MRI",
abstract = "Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, characterised by a rapid and irregular electrical activation of the atria. Treatments for AF are often ineffective and few atrial biomarkers exist to automatically characterise atrial function and aid in treatment selection for AF. Clinical metrics of left atrial (LA) function, such as ejection fraction (EF) and active atrial contraction ejection fraction (aEF), are promising, but have until now typically relied on volume estimations extrapolated from single-slice images. In this work, we study volumetric functional biomarkers of the LA using a fully automatic SEGmentation of the left Atrium based on a convolutional neural Network (SEGANet). SEGANet was trained using a dedicated data augmentation scheme to segment the LA, across all cardiac phases, in short axis dynamic (CINE) Magnetic Resonance Images (MRI) acquired with full cardiac coverage. Using the automatic segmentations, we plotted volumetric time curves for the LA and estimated LA EF and aEF automatically. The proposed method yields high quality segmentations that compare well with manual segmentations (Dice scores [ 0.93 ± 0.04 ], median contour [ 0.75 ± 0.31 ] mm and Hausdorff distances [ 4.59 ± 2.06 ] mm). LA EF and aEF are also in agreement with literature values and are significantly higher in AF patients than in healthy volunteers. Our work opens up the possibility of automatically estimating LA volumes and functional biomarkers from multi-slice CINE MRI, bypassing the limitations of current single-slice methods and improving the characterisation of atrial function in AF patients.",
keywords = "Atrial fibrillation, CINE MRI, Convolutional neural network, Ejection fraction, Left atrium, Segmentation",
author = "Ana Louren{\c c}o and Eric Kerfoot and Connor Dibblin and Ebraham Alskaf and Mustafa Anjari and Bharath, {Anil A.} and King, {Andrew P.} and Henry Chubb and Correia, {Teresa M.} and Marta Varela",
note = "Funding Information: This research was supported by the Wellcome EPSRC Centre for Medical Engineering at the School of Biomedical Engineering and Imaging Sciences, King?s College London [WT203148/Z/16/Z] and the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy?s and St Thomas? NHS Foundation Trust and King?s College London. We also acknowledge funding from the Engineering and Physical Sciences Research Council [EP/N026993/1] and the British Heart Foundation [RE/18/4/34215].). Publisher Copyright: {\textcopyright} 2021, Springer Nature Switzerland AG. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.; 11th International Workshop on Statistical Atlases and Computational Models of the Heart, STACOM 2020 held in Conjunction with MICCAI 2020 ; Conference date: 04-10-2020 Through 04-10-2020",
year = "2021",
doi = "10.1007/978-3-030-68107-4_14",
language = "English",
isbn = "9783030681067",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "137--145",
editor = "{Puyol Anton}, Esther and Mihaela Pop and Maxime Sermesant and Victor Campello and Alain Lalande and Karim Lekadir and Avan Suinesiaputra and Oscar Camara and Alistair Young",
booktitle = "Statistical Atlases and Computational Models of the Heart. MandMs and EMIDEC Challenges - 11th International Workshop, STACOM 2020, Held in Conjunction with MICCAI 2020, Revised Selected Papers",
address = "Germany",
}