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Left entorhinal cortex and object recognition

Research output: Contribution to journalArticlepeer-review

Adele James, Tim J. von Oertzen, Ray Norbury, Hans-Juergen Huppertz, Karen R. Brandt

Original languageEnglish
Pages (from-to)363-367
Number of pages3
Issue number5
Accepted/In press29 Dec 2017
Published21 Mar 2018


King's Authors


The present research explored the role of the medial temporal lobes in object memory in the unique patient MR, who has a selective lesion to her left lateral entorhinal cortex. Two experiments explored recognition memory for object identity and object location in MR and matched controls. The results showed that MR had intact performance in an object location task [MR=0.70, controls=0.69, t(6)=0.06, P>0.05], but was impaired in an object identity task [MR=0.62, controls=0.84, t(6)=-4.12, P<0.05]. No differences in correct recollection or familiarity emerged. These results suggest a differential role of the entorhinal cortex in object recognition memory. The current research is therefore the first patient study to show the role of the lateral entorhinal cortex in object identity recognition and suggests that current medial temporal lobe theoretical models on both object and recognition memory require a theoretical re-think to account for the contributions of the entorhinal cortex in these processes.

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