King's College London

Research portal

Les leucomalacies périventriculaires. II. Diagnostic, séquelles et neuroprotection

Research output: Contribution to journalArticle

S Marret, V Zupan, P Gressens, H Lagercrantz, P Evrard

Original languageFrench
Pages (from-to)538-45
Number of pages8
JournalArchives De Pediatrie
Issue number5
Publication statusPublished - May 1998

King's Authors


The term 'periventricular leukomalacia' (PVL) usually covers necrotic and/or gliotic lesions from perinatal origin occurring in the periventricular ring of telencephalic white matter. Carrying motor and neuropsychological consequences, PVLs could be the most severe danger for very premature brains. Positive rolandic sharp waves recorded on EEG and precocious abnormally echogenous periventricular images on ultrasound suggest prospective periventricular cysts. Cystic periventricular cavitations certify the diagnosis of PVL. More subtle lesions of PVL do not reach the cystic grade and their diagnosis is confirmed by MRI. Treatment of infections is already available and potentially a tool for prevention. When the overwhelming glutamatergic signal has been triggered, neuroprotective agents turning off the excitotoxic cascade, including calcium blockers, growth factors and others, are promising therapeutic tools.

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454