Abstract
Lesion symptom mapping has revolutionized our understanding of the functioning of the human brain. Associating damaged voxels in the brain with loss of function has created a map of the brain that identifies critical areas. While these methods have significantly advanced our understanding, recent improvements have identified the need for multivariate and multimodal methods to map hidden lesions and damage to white matter networks beyond the lesion voxels. This chapter reviews the evolution of lesion-symptom mapping from single case studies to the human disconnectome. Glossary Disconnectome-Clinical-neuroanatomical correlation methods based on the study of the disruption of the white matter connectome by lesions Pseudonormalization-A dynamic signal change seen in the subacute stage of the ischemic stroke where the diffusion signal appears in the range of healthy tissue masking an underlying lesion. Voxel-based lesion-symptom mapping-Clinical-neuroanatomical differential method based on the study of lesioned voxels and psychometric assessments Metabolic disconnection-Brain regions are structurally connected to work together through co-activation, inhibition or disinhibition. These processes can be interrupted functionally without an evident lesion on conventional structural imaging, which is considered as metabolic disconnection. Structural negative MRI scan-Magnetic resonance imaging (MRI) structural scans do not reveal a lesion despite clinical symptoms of patients suggesting the presence of a brain lesion.
| Original language | English |
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| Title of host publication | Encyclopaedia of Behavioural Neuroscience |
| Edition | 2 |
| DOIs | |
| Publication status | Accepted/In press - 2020 |