Less Invasive Surfactant Administration (LISA) in very prematurely born infants

Sandeep Shetty, Helen Egan, Peter Cornuaud, Anay Kulkarni, Donovan Duffy, Anne Greenough

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Abstract

Background: Less invasive surfactant administration (LISA) is the preferred mode of surfactant administration for spontaneously breathing preterm babies supported by noninvasive ventilation (NIV). Objective: To determine whether LISA on the neonatal unit or in the delivery suite reduced bronchopulmonary dysplasia (BPD) or the need for intubation, or lower durations of invasive ventilation and length of hospital stay (LOS). Methods: A historical comparison was undertaken. Each “LISA” infant was matched with two infants (controls) who did not receive LISA. Results: The 25 LISA infants had similar gestational ages and birth weights to the 50 controls (28 (25.6 - 31.7) weeks versus 28.5 (25.4 - 31.9) weeks, p=0.732; 1120 (580-1810) grams versus 1070 (540-1869) grams, p=0.928) respectively. LISA infants had lower requirement for intubation (52% versus 90%, p<0.001), shorter duration of invasive ventilation (median 1(0-35) days versus 6 (0-62) days p=0.001) and a lower incidence of BPD (36% versus 64%, p=0.022). There were no significant differences in duration of NIV (median 26 (3-225) versus 23 (2-85) days, p=0.831) or the total LOS (median 76 (24-259) versus 85 (27-221), p=0.238). Conclusion: LISA on the neonatal unit or the delivery suite was associated with a lower BPD incidence, need for intubation and duration of invasive ventilation.
Original languageEnglish
JournalAJP Reports
Publication statusPublished - 2021

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