Leukocytes and the Natural History of Deep Vein Thrombosis Current Concepts and Future Directions

Prakash Saha; Julia Humphries; Bijan Modarai; Katherine Mattock; Matthew Waltham; Colin Evans; Anwar Ahmad; Ashish Patel; Sobath Premaratne; Oliver T. A. Lyons; Alberto Smith

doi:10.1161/ATVBAHA.110.213405

Leukocytes and the Natural History of Deep Vein Thrombosis Current Concepts and Future Directions

Prakash Saha, Julia Humphries, Bijan Modarai, Katherine Mattock, Matthew Waltham, Colin Evans, Anwar Ahmad, Ashish Patel, Sobath Premaratne, Oliver T. A. Lyons, Alberto Smith

Vascular Risk & Surgery

Research output: Contribution to journal › Article › peer-review

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Abstract

Observational studies have shown that inflammatory cells accumulate within the thrombus and surrounding vein wall during the natural history of venous thrombosis. More recent studies have begun to unravel the mechanisms that regulate this interaction and have confirmed that thrombosis and inflammation are intimately linked. This review outlines our current knowledge of the complex relationship between inflammatory cell activity and venous thrombosis and highlights new areas of research in this field. A better understanding of this relationship could lead to the development of novel therapeutic targets that inhibit thrombus formation or promote its resolution.

Original language	English
Pages (from-to)	506 - 512
Number of pages	7
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	31
Issue number	3
DOIs	https://doi.org/10.1161/ATVBAHA.110.213405
Publication status	Published - Mar 2011

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10.1161/ATVBAHA.110.213405

Leukocytes and the natural history_SAHA Accepted 21Dec2010 GREENAAMAccepted author manuscript, 874 KB

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abstract = "Observational studies have shown that inflammatory cells accumulate within the thrombus and surrounding vein wall during the natural history of venous thrombosis. More recent studies have begun to unravel the mechanisms that regulate this interaction and have confirmed that thrombosis and inflammation are intimately linked. This review outlines our current knowledge of the complex relationship between inflammatory cell activity and venous thrombosis and highlights new areas of research in this field. A better understanding of this relationship could lead to the development of novel therapeutic targets that inhibit thrombus formation or promote its resolution.",

author = "Prakash Saha and Julia Humphries and Bijan Modarai and Katherine Mattock and Matthew Waltham and Colin Evans and Anwar Ahmad and Ashish Patel and Sobath Premaratne and Lyons, {Oliver T. A.} and Alberto Smith",

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AU - Mattock, Katherine

AU - Waltham, Matthew

AU - Evans, Colin

AU - Ahmad, Anwar

AU - Patel, Ashish

AU - Premaratne, Sobath

AU - Lyons, Oliver T. A.

AU - Smith, Alberto

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AB - Observational studies have shown that inflammatory cells accumulate within the thrombus and surrounding vein wall during the natural history of venous thrombosis. More recent studies have begun to unravel the mechanisms that regulate this interaction and have confirmed that thrombosis and inflammation are intimately linked. This review outlines our current knowledge of the complex relationship between inflammatory cell activity and venous thrombosis and highlights new areas of research in this field. A better understanding of this relationship could lead to the development of novel therapeutic targets that inhibit thrombus formation or promote its resolution.

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JF - Arteriosclerosis, Thrombosis, and Vascular Biology

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Leukocytes and the Natural History of Deep Vein Thrombosis Current Concepts and Future Directions

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