Adopting a back-translation strategy using stem cell biology to inform epidemiological analyses, here we show associations between cellular readouts of NSC maintenance and expression levels of nutrient-sensing genes following NSC exposure to aging human serum as well as morphological and gene expression alterations following repeated passaging. Epidemiological analyses on the identified genes showed associations between polymorphisms in SIRT1 and ABTB1 and cognitive performance as well as interactions between SIRT1 genotype and physical activity and between GRB10 genotype and adherence to a Mediterranean diet.
Our study contributes to the understanding of neural stem cell molecular mechanisms underlying human cognitive aging and hints at lifestyle modifiable factors.
- nsulin-like growth-factor1 signaling
- Mediterranean diet
- Paired Associates Learning
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Does The Ageing Systemic Milieu Alter Neural Stem Cell Activity? : Cellular And Molecular Evidence From A Human SystemAuthor: Murphy, T. A., 2016
Student thesis: Doctoral Thesis › Doctor of Philosophy
Investigating Nutrient-Sensing Pathways in Ageing Human Neural Stem Cells and Age-Related Cognitive DeclineAuthor: De Lucia, C., 1 Apr 2019
Student thesis: Doctoral Thesis › Doctor of PhilosophyFile