Limbic and prefrontal responses to facial emotion expressions in depersonalization

E Lemche; S A Surguladze; Vincent Giampietro; A Anilkumar; M J Brammer; M Sierra; X Chitnis; S C R Williams; D Gasston; P Joraschky; A S David; M L Phillips

doi:10.1097/WNR.0b013e328057deb3

Limbic and prefrontal responses to facial emotion expressions in depersonalization

E Lemche, S A Surguladze, Vincent Giampietro, A Anilkumar, M J Brammer, M Sierra, X Chitnis, S C R Williams, D Gasston, P Joraschky, A S David, M L Phillips

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Abstract

Depersonalization disorder, characterized by emotional detachment, has been associated with increased prefrontal cortical and decreased autonomic activity to emotional stimuli. Event-related fMRI with simultaneous measurements of skin conductance levels occurred in nine depersonalization disorder patients and 12 normal controls to neutral, mild and intense happy and sad facial expressions. Patients, but not controls, showed decreases in subcortical limbic activity to increasingly intense happy and sad facial expressions, respectively. For both happy and sad expressions, negative correlations between skin conductance measures in bilateral dorsal prefrontal cortices occurred only in depersonalization disorder patients. Abnormal decreases in limbic activity to increasingly intense emotional expressions, and increases in dorsal prefrontal cortical activity to emotionally arousing stimuli may underlie the emotional detachment of depersonalization disorder

Original language	English
Pages (from-to)	473 - 477
Number of pages	5
Journal	Neuroreport
Volume	18
Issue number	5
DOIs	https://doi.org/10.1097/WNR.0b013e328057deb3
Publication status	Published - Mar 2007

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title = "Limbic and prefrontal responses to facial emotion expressions in depersonalization",

abstract = "Depersonalization disorder, characterized by emotional detachment, has been associated with increased prefrontal cortical and decreased autonomic activity to emotional stimuli. Event-related fMRI with simultaneous measurements of skin conductance levels occurred in nine depersonalization disorder patients and 12 normal controls to neutral, mild and intense happy and sad facial expressions. Patients, but not controls, showed decreases in subcortical limbic activity to increasingly intense happy and sad facial expressions, respectively. For both happy and sad expressions, negative correlations between skin conductance measures in bilateral dorsal prefrontal cortices occurred only in depersonalization disorder patients. Abnormal decreases in limbic activity to increasingly intense emotional expressions, and increases in dorsal prefrontal cortical activity to emotionally arousing stimuli may underlie the emotional detachment of depersonalization disorder",

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T1 - Limbic and prefrontal responses to facial emotion expressions in depersonalization

AU - Lemche, E

AU - Surguladze, S A

AU - Giampietro, Vincent

AU - Anilkumar, A

AU - Brammer, M J

AU - Sierra, M

AU - Chitnis, X

AU - Williams, S C R

AU - Gasston, D

AU - Joraschky, P

AU - David, A S

AU - Phillips, M L

PY - 2007/3

Y1 - 2007/3

N2 - Depersonalization disorder, characterized by emotional detachment, has been associated with increased prefrontal cortical and decreased autonomic activity to emotional stimuli. Event-related fMRI with simultaneous measurements of skin conductance levels occurred in nine depersonalization disorder patients and 12 normal controls to neutral, mild and intense happy and sad facial expressions. Patients, but not controls, showed decreases in subcortical limbic activity to increasingly intense happy and sad facial expressions, respectively. For both happy and sad expressions, negative correlations between skin conductance measures in bilateral dorsal prefrontal cortices occurred only in depersonalization disorder patients. Abnormal decreases in limbic activity to increasingly intense emotional expressions, and increases in dorsal prefrontal cortical activity to emotionally arousing stimuli may underlie the emotional detachment of depersonalization disorder

AB - Depersonalization disorder, characterized by emotional detachment, has been associated with increased prefrontal cortical and decreased autonomic activity to emotional stimuli. Event-related fMRI with simultaneous measurements of skin conductance levels occurred in nine depersonalization disorder patients and 12 normal controls to neutral, mild and intense happy and sad facial expressions. Patients, but not controls, showed decreases in subcortical limbic activity to increasingly intense happy and sad facial expressions, respectively. For both happy and sad expressions, negative correlations between skin conductance measures in bilateral dorsal prefrontal cortices occurred only in depersonalization disorder patients. Abnormal decreases in limbic activity to increasingly intense emotional expressions, and increases in dorsal prefrontal cortical activity to emotionally arousing stimuli may underlie the emotional detachment of depersonalization disorder

U2 - 10.1097/WNR.0b013e328057deb3

DO - 10.1097/WNR.0b013e328057deb3

M3 - Article

VL - 18

SP - 473

EP - 477

JO - Neuroreport

JF - Neuroreport

IS - 5

ER -

Limbic and prefrontal responses to facial emotion expressions in depersonalization

Abstract

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