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LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration

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LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration. / Infante, Elvira; Castagnino, Alessia; Ferrari, Robin; Monteiro, Pedro; Agüera-gonzález, Sonia; Paul-gilloteaux, Perrine; Domingues, Mélanie J.; Maiuri, Paolo; Raab, Matthew; Shanahan, Catherine M.; Baffet, Alexandre; Piel, Matthieu; Gomes, Edgar R.; Chavrier, Philippe.

In: Nature Communications, Vol. 9, No. 1, 01.12.2018.

Research output: Contribution to journalArticle

Harvard

Infante, E, Castagnino, A, Ferrari, R, Monteiro, P, Agüera-gonzález, S, Paul-gilloteaux, P, Domingues, MJ, Maiuri, P, Raab, M, Shanahan, CM, Baffet, A, Piel, M, Gomes, ER & Chavrier, P 2018, 'LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration', Nature Communications, vol. 9, no. 1. https://doi.org/10.1038/s41467-018-04865-7

APA

Infante, E., Castagnino, A., Ferrari, R., Monteiro, P., Agüera-gonzález, S., Paul-gilloteaux, P., ... Chavrier, P. (2018). LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration. Nature Communications, 9(1). https://doi.org/10.1038/s41467-018-04865-7

Vancouver

Infante E, Castagnino A, Ferrari R, Monteiro P, Agüera-gonzález S, Paul-gilloteaux P et al. LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration. Nature Communications. 2018 Dec 1;9(1). https://doi.org/10.1038/s41467-018-04865-7

Author

Infante, Elvira ; Castagnino, Alessia ; Ferrari, Robin ; Monteiro, Pedro ; Agüera-gonzález, Sonia ; Paul-gilloteaux, Perrine ; Domingues, Mélanie J. ; Maiuri, Paolo ; Raab, Matthew ; Shanahan, Catherine M. ; Baffet, Alexandre ; Piel, Matthieu ; Gomes, Edgar R. ; Chavrier, Philippe. / LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration. In: Nature Communications. 2018 ; Vol. 9, No. 1.

Bibtex Download

@article{a4b0bde7f09c44d7a3c8cfb4d4444ac3,
title = "LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration",
abstract = "Cancer cells’ ability to migrate through constricting pores in the tissue matrix is limited by nuclear stiffness. MT1-MMP contributes to metastasis by widening matrix pores, facilitating confined migration. Here, we show that modulation of matrix pore size or of lamin A expression known to modulate nuclear stiffness directly impinges on levels of MT1-MMP-mediated pericellular collagenolysis by cancer cells. A component of this adaptive response is the centrosome-centered distribution of MT1-MMP intracellular storage compartments ahead of the nucleus. We further show that this response, including invadopodia formation in association with confining matrix fibrils, requires an intact connection between the nucleus and the centrosome via the linker of nucleoskeleton and cytoskeleton (LINC) complex protein nesprin-2 and dynein adaptor Lis1. Our results uncover a digest-on-demand strategy for nuclear translocation through constricted spaces whereby confined migration triggers polarization of MT1-MMP storage compartments and matrix proteolysis in front of the nucleus depending on nucleus-microtubule linkage.",
author = "Elvira Infante and Alessia Castagnino and Robin Ferrari and Pedro Monteiro and Sonia Ag{\"u}era-gonzález and Perrine Paul-gilloteaux and Domingues, {M{\'e}lanie J.} and Paolo Maiuri and Matthew Raab and Shanahan, {Catherine M.} and Alexandre Baffet and Matthieu Piel and Gomes, {Edgar R.} and Philippe Chavrier",
year = "2018",
month = "12",
day = "1",
doi = "10.1038/s41467-018-04865-7",
language = "English",
volume = "9",
journal = "Nat Commun",
issn = "2041-1723",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration

AU - Infante, Elvira

AU - Castagnino, Alessia

AU - Ferrari, Robin

AU - Monteiro, Pedro

AU - Agüera-gonzález, Sonia

AU - Paul-gilloteaux, Perrine

AU - Domingues, Mélanie J.

AU - Maiuri, Paolo

AU - Raab, Matthew

AU - Shanahan, Catherine M.

AU - Baffet, Alexandre

AU - Piel, Matthieu

AU - Gomes, Edgar R.

AU - Chavrier, Philippe

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Cancer cells’ ability to migrate through constricting pores in the tissue matrix is limited by nuclear stiffness. MT1-MMP contributes to metastasis by widening matrix pores, facilitating confined migration. Here, we show that modulation of matrix pore size or of lamin A expression known to modulate nuclear stiffness directly impinges on levels of MT1-MMP-mediated pericellular collagenolysis by cancer cells. A component of this adaptive response is the centrosome-centered distribution of MT1-MMP intracellular storage compartments ahead of the nucleus. We further show that this response, including invadopodia formation in association with confining matrix fibrils, requires an intact connection between the nucleus and the centrosome via the linker of nucleoskeleton and cytoskeleton (LINC) complex protein nesprin-2 and dynein adaptor Lis1. Our results uncover a digest-on-demand strategy for nuclear translocation through constricted spaces whereby confined migration triggers polarization of MT1-MMP storage compartments and matrix proteolysis in front of the nucleus depending on nucleus-microtubule linkage.

AB - Cancer cells’ ability to migrate through constricting pores in the tissue matrix is limited by nuclear stiffness. MT1-MMP contributes to metastasis by widening matrix pores, facilitating confined migration. Here, we show that modulation of matrix pore size or of lamin A expression known to modulate nuclear stiffness directly impinges on levels of MT1-MMP-mediated pericellular collagenolysis by cancer cells. A component of this adaptive response is the centrosome-centered distribution of MT1-MMP intracellular storage compartments ahead of the nucleus. We further show that this response, including invadopodia formation in association with confining matrix fibrils, requires an intact connection between the nucleus and the centrosome via the linker of nucleoskeleton and cytoskeleton (LINC) complex protein nesprin-2 and dynein adaptor Lis1. Our results uncover a digest-on-demand strategy for nuclear translocation through constricted spaces whereby confined migration triggers polarization of MT1-MMP storage compartments and matrix proteolysis in front of the nucleus depending on nucleus-microtubule linkage.

U2 - 10.1038/s41467-018-04865-7

DO - 10.1038/s41467-018-04865-7

M3 - Article

VL - 9

JO - Nat Commun

JF - Nat Commun

SN - 2041-1723

IS - 1

ER -

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