Linkage study of the D-5 dopamine receptor gene (DRD5) in multiplex Icelandic and English schizophrenia pedigrees

TY - JOUR

T1 - Linkage study of the D-5 dopamine receptor gene (DRD5) in multiplex Icelandic and English schizophrenia pedigrees

AU - Kalsi, G

AU - Sherrington, R

AU - Mankoo, BS

AU - Brynjolfsson, J

AU - Sigmundsson, T

AU - Curtis, D

AU - Read, T

AU - Murphy, P

AU - Butler, R

AU - Petursson, H

AU - Gurling, HMD

PY - 1996/1

Y1 - 1996/1

N2 - Objective: The authors investigated the possibility that genetic variation or mutation of the dopamine D-5 receptor gene might modify susceptibility to schizophrenia. Method: Twenty-three Icelandic and English pedigrees containing multiple cases of schizophrenia were genotyped by using a highly informative microsatellite for the D-5 dopamine receptor gene DRD5. Results: By means of three different affection models, negative lod scores were obtained under assumptions of autosomal dominant and recessive inheritance. There was no evidence for locus heterogeneity. Nonparametric extended relative pair analysis also produced negative results. Conclusions: These data indicate that mutations of the D-5 dopamine receptor gene ave not a major cause of schizophrenia in these pedigrees. Because of the probable existence of locus heterogeneity, the D-5 receptor gene may be of etiologic importance in other families with schizophrenia.

AB - Objective: The authors investigated the possibility that genetic variation or mutation of the dopamine D-5 receptor gene might modify susceptibility to schizophrenia. Method: Twenty-three Icelandic and English pedigrees containing multiple cases of schizophrenia were genotyped by using a highly informative microsatellite for the D-5 dopamine receptor gene DRD5. Results: By means of three different affection models, negative lod scores were obtained under assumptions of autosomal dominant and recessive inheritance. There was no evidence for locus heterogeneity. Nonparametric extended relative pair analysis also produced negative results. Conclusions: These data indicate that mutations of the D-5 dopamine receptor gene ave not a major cause of schizophrenia in these pedigrees. Because of the probable existence of locus heterogeneity, the D-5 receptor gene may be of etiologic importance in other families with schizophrenia.

KW - LOCUS

KW - AFFINITY

KW - CLONING

M3 - Article

SN - 0002-953X

VL - 153

SP - 107

EP - 109

JO - The American Journal of Psychiatry

JF - The American Journal of Psychiatry

IS - 1

ER -