Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings

Kaixin Zhou; Philip Asherson; Pak Sham; Barbara Franke; Richard J. L. Anney; Jan Buitelaar; Richard Ebstein; Michael Gill; Keeley Brookes; Cathelijne Buschgens; Desmond Campbell; Wai Chen; Hanna Christiansen; Ellen Fliers; Isabel Gabris; Lena Johansson; Rafaela Marco; Fernando Mulas; Ueli Mueller; Aisling Mulligan; Benjamin M. Neale; Fruhling Rijsdijk; Nanda Rommelse; Henrik Uebel; Lamprini Psychogiou; Xiaohui Xu; Tobias Banaschewski; Edmund Sonuga-Barke; Jacques Eisenberg; Iris Manor; Ana Miranda; Robert D. Oades; Herbert Roeyers; Aribert Rothenberger; Joseph Sergeant; Hans-Christoph Steinhausen; Eric Taylor; Margaret Thompson; Stephen V. Faraone

doi:10.1016/j.biopsych.2008.02.024

Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings

Kaixin Zhou, Philip Asherson, Pak Sham, Barbara Franke, Richard J. L. Anney, Jan Buitelaar, Richard Ebstein, Michael Gill, Keeley Brookes, Cathelijne Buschgens, Desmond Campbell, Wai Chen, Hanna Christiansen, Ellen Fliers, Isabel Gabris, Lena Johansson, Rafaela Marco, Fernando Mulas, Ueli Mueller, Aisling MulliganBenjamin M. Neale, Fruhling Rijsdijk, Nanda Rommelse, Henrik Uebel, Lamprini Psychogiou, Xiaohui Xu, Tobias Banaschewski, Edmund Sonuga-Barke, Jacques Eisenberg, Iris Manor, Ana Miranda, Robert D. Oades, Herbert Roeyers, Aribert Rothenberger, Joseph Sergeant, Hans-Christoph Steinhausen, Eric Taylor, Margaret Thompson, Stephen V. Faraone

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). Methods: A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. Results: A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p

Original language	English
Pages (from-to)	571 - 576
Number of pages	6
Journal	Biological psychiatry
Volume	64
Issue number	7
DOIs	https://doi.org/10.1016/j.biopsych.2008.02.024
Publication status	Published - 1 Oct 2008

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Zhou, K., Asherson, P., Sham, P., Franke, B., Anney, R. J. L., Buitelaar, J., Ebstein, R., Gill, M., Brookes, K., Buschgens, C., Campbell, D., Chen, W., Christiansen, H., Fliers, E., Gabris, I., Johansson, L., Marco, R., Mulas, F., Mueller, U., ... Faraone, S. V. (2008). Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings. Biological psychiatry, 64(7), 571 - 576. https://doi.org/10.1016/j.biopsych.2008.02.024

@article{8c82c23d778c45ce80c82a1b2910fbe6,

title = "Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings",

abstract = "Background: Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). Methods: A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. Results: A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p ",

author = "Kaixin Zhou and Philip Asherson and Pak Sham and Barbara Franke and Anney, {Richard J. L.} and Jan Buitelaar and Richard Ebstein and Michael Gill and Keeley Brookes and Cathelijne Buschgens and Desmond Campbell and Wai Chen and Hanna Christiansen and Ellen Fliers and Isabel Gabris and Lena Johansson and Rafaela Marco and Fernando Mulas and Ueli Mueller and Aisling Mulligan and Neale, {Benjamin M.} and Fruhling Rijsdijk and Nanda Rommelse and Henrik Uebel and Lamprini Psychogiou and Xiaohui Xu and Tobias Banaschewski and Edmund Sonuga-Barke and Jacques Eisenberg and Iris Manor and Ana Miranda and Oades, {Robert D.} and Herbert Roeyers and Aribert Rothenberger and Joseph Sergeant and Hans-Christoph Steinhausen and Eric Taylor and Margaret Thompson and Faraone, {Stephen V.}",

year = "2008",

month = oct,

day = "1",

doi = "10.1016/j.biopsych.2008.02.024",

language = "English",

volume = "64",

pages = "571 -- 576",

journal = "Biological psychiatry",

issn = "0006-3223",

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Zhou, K, Asherson, P, Sham, P, Franke, B, Anney, RJL, Buitelaar, J, Ebstein, R, Gill, M, Brookes, K, Buschgens, C, Campbell, D, Chen, W, Christiansen, H, Fliers, E, Gabris, I, Johansson, L, Marco, R, Mulas, F, Mueller, U, Mulligan, A, Neale, BM, Rijsdijk, F, Rommelse, N, Uebel, H, Psychogiou, L, Xu, X, Banaschewski, T, Sonuga-Barke, E, Eisenberg, J, Manor, I, Miranda, A, Oades, RD, Roeyers, H, Rothenberger, A, Sergeant, J, Steinhausen, H-C, Taylor, E, Thompson, M & Faraone, SV 2008, 'Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings', Biological psychiatry, vol. 64, no. 7, pp. 571 - 576. https://doi.org/10.1016/j.biopsych.2008.02.024

TY - JOUR

T1 - Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings

AU - Zhou, Kaixin

AU - Asherson, Philip

AU - Sham, Pak

AU - Franke, Barbara

AU - Anney, Richard J. L.

AU - Buitelaar, Jan

AU - Ebstein, Richard

AU - Gill, Michael

AU - Brookes, Keeley

AU - Buschgens, Cathelijne

AU - Campbell, Desmond

AU - Chen, Wai

AU - Christiansen, Hanna

AU - Fliers, Ellen

AU - Gabris, Isabel

AU - Johansson, Lena

AU - Marco, Rafaela

AU - Mulas, Fernando

AU - Mueller, Ueli

AU - Mulligan, Aisling

AU - Neale, Benjamin M.

AU - Rijsdijk, Fruhling

AU - Rommelse, Nanda

AU - Uebel, Henrik

AU - Psychogiou, Lamprini

AU - Xu, Xiaohui

AU - Banaschewski, Tobias

AU - Sonuga-Barke, Edmund

AU - Eisenberg, Jacques

AU - Manor, Iris

AU - Miranda, Ana

AU - Oades, Robert D.

AU - Roeyers, Herbert

AU - Rothenberger, Aribert

AU - Sergeant, Joseph

AU - Steinhausen, Hans-Christoph

AU - Taylor, Eric

AU - Thompson, Margaret

AU - Faraone, Stephen V.

PY - 2008/10/1

Y1 - 2008/10/1

N2 - Background: Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). Methods: A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. Results: A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p

AB - Background: Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). Methods: A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. Results: A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p

U2 - 10.1016/j.biopsych.2008.02.024

DO - 10.1016/j.biopsych.2008.02.024

M3 - Article

SN - 0006-3223

VL - 64

SP - 571

EP - 576

JO - Biological psychiatry

JF - Biological psychiatry

IS - 7

ER -

Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings

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