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Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings

Research output: Contribution to journalArticle

Kaixin Zhou, Philip Asherson, Pak Sham, Barbara Franke, Richard J. L. Anney, Jan Buitelaar, Richard Ebstein, Michael Gill, Keeley Brookes, Cathelijne Buschgens, Desmond Campbell, Wai Chen, Hanna Christiansen, Ellen Fliers, Isabel Gabris, Lena Johansson, Rafaela Marco, Fernando Mulas, Ueli Mueller, Aisling Mulligan & 19 more Benjamin M. Neale, Fruhling Rijsdijk, Nanda Rommelse, Henrik Uebel, Lamprini Psychogiou, Xiaohui Xu, Tobias Banaschewski, Edmund Sonuga-Barke, Jacques Eisenberg, Iris Manor, Ana Miranda, Robert D. Oades, Herbert Roeyers, Aribert Rothenberger, Joseph Sergeant, Hans-Christoph Steinhausen, Eric Taylor, Margaret Thompson, Stephen V. Faraone

Original languageEnglish
Pages (from-to)571 - 576
Number of pages6
JournalBiological psychiatry
Issue number7
Publication statusPublished - 1 Oct 2008

King's Authors


Background: Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). Methods: A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. Results: A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p

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